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The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population

We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of...

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Autores principales: Gamboa, Ricardo, Huesca-Gómez, Claudia, López-Pérez, Vanessa, Posadas-Sánchez, Rosalinda, Cardoso-Saldaña, Guillermo, Medina-Urrutia, Aida, Juárez-Rojas, Juan Gabriel, Soto, María Elena, Posadas-Romero, Carlos, Vargas-Alarcón, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082227/
https://www.ncbi.nlm.nih.gov/pubmed/29786102
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0008
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author Gamboa, Ricardo
Huesca-Gómez, Claudia
López-Pérez, Vanessa
Posadas-Sánchez, Rosalinda
Cardoso-Saldaña, Guillermo
Medina-Urrutia, Aida
Juárez-Rojas, Juan Gabriel
Soto, María Elena
Posadas-Romero, Carlos
Vargas-Alarcón, Gilberto
author_facet Gamboa, Ricardo
Huesca-Gómez, Claudia
López-Pérez, Vanessa
Posadas-Sánchez, Rosalinda
Cardoso-Saldaña, Guillermo
Medina-Urrutia, Aida
Juárez-Rojas, Juan Gabriel
Soto, María Elena
Posadas-Romero, Carlos
Vargas-Alarcón, Gilberto
author_sort Gamboa, Ricardo
collection PubMed
description We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.
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spelling pubmed-60822272018-08-17 The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population Gamboa, Ricardo Huesca-Gómez, Claudia López-Pérez, Vanessa Posadas-Sánchez, Rosalinda Cardoso-Saldaña, Guillermo Medina-Urrutia, Aida Juárez-Rojas, Juan Gabriel Soto, María Elena Posadas-Romero, Carlos Vargas-Alarcón, Gilberto Genet Mol Biol Human and Medical Genetics We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors. Sociedade Brasileira de Genética 2018-05-21 2018 /pmc/articles/PMC6082227/ /pubmed/29786102 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0008 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Gamboa, Ricardo
Huesca-Gómez, Claudia
López-Pérez, Vanessa
Posadas-Sánchez, Rosalinda
Cardoso-Saldaña, Guillermo
Medina-Urrutia, Aida
Juárez-Rojas, Juan Gabriel
Soto, María Elena
Posadas-Romero, Carlos
Vargas-Alarcón, Gilberto
The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title_full The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title_fullStr The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title_full_unstemmed The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title_short The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
title_sort ucp2 -866g/a, ala55val and ucp3 -55c/t polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in mexican population
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082227/
https://www.ncbi.nlm.nih.gov/pubmed/29786102
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0008
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