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An association study of FOXO3 variant and longevity

Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity le...

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Autores principales: Silva-Sena, Geralda Gillian, Camporez, Daniela, dos Santos, Lígia Ramos, da Silva, Aline Sesana, Sagrillo Pimassoni, Lúcia Helena, Tieppo, Alessandra, Pimentel Batitucci, Maria do Carmo, Morelato, Renato Lírio, de Paula, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082243/
https://www.ncbi.nlm.nih.gov/pubmed/30088610
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0169
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author Silva-Sena, Geralda Gillian
Camporez, Daniela
dos Santos, Lígia Ramos
da Silva, Aline Sesana
Sagrillo Pimassoni, Lúcia Helena
Tieppo, Alessandra
Pimentel Batitucci, Maria do Carmo
Morelato, Renato Lírio
de Paula, Flavia
author_facet Silva-Sena, Geralda Gillian
Camporez, Daniela
dos Santos, Lígia Ramos
da Silva, Aline Sesana
Sagrillo Pimassoni, Lúcia Helena
Tieppo, Alessandra
Pimentel Batitucci, Maria do Carmo
Morelato, Renato Lírio
de Paula, Flavia
author_sort Silva-Sena, Geralda Gillian
collection PubMed
description Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.
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spelling pubmed-60822432018-08-17 An association study of FOXO3 variant and longevity Silva-Sena, Geralda Gillian Camporez, Daniela dos Santos, Lígia Ramos da Silva, Aline Sesana Sagrillo Pimassoni, Lúcia Helena Tieppo, Alessandra Pimentel Batitucci, Maria do Carmo Morelato, Renato Lírio de Paula, Flavia Genet Mol Biol Human and Medical Genetics Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals. Sociedade Brasileira de Genética 2018-06-11 2018 /pmc/articles/PMC6082243/ /pubmed/30088610 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0169 Text en Copyright © 2018, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
Silva-Sena, Geralda Gillian
Camporez, Daniela
dos Santos, Lígia Ramos
da Silva, Aline Sesana
Sagrillo Pimassoni, Lúcia Helena
Tieppo, Alessandra
Pimentel Batitucci, Maria do Carmo
Morelato, Renato Lírio
de Paula, Flavia
An association study of FOXO3 variant and longevity
title An association study of FOXO3 variant and longevity
title_full An association study of FOXO3 variant and longevity
title_fullStr An association study of FOXO3 variant and longevity
title_full_unstemmed An association study of FOXO3 variant and longevity
title_short An association study of FOXO3 variant and longevity
title_sort association study of foxo3 variant and longevity
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082243/
https://www.ncbi.nlm.nih.gov/pubmed/30088610
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0169
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