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Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a f...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082319/ https://www.ncbi.nlm.nih.gov/pubmed/29869195 http://dx.doi.org/10.1007/s12551-018-0431-6 |
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author | Stroud, Matthew J. |
author_facet | Stroud, Matthew J. |
author_sort | Stroud, Matthew J. |
collection | PubMed |
description | The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a functional LINC complex is highlighted by the large number of mutations in genes encoding LINC complex proteins that lead to skeletal and cardiac myopathies. In this review, the structure, function, and interactions between components of the LINC complex will be described. Mutations that are known to cause cardiomyopathy in patients will be discussed alongside their respective mouse models. Furthermore, future challenges for the field and emerging technologies to investigate LINC complex function will be discussed. |
format | Online Article Text |
id | pubmed-6082319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-60823192018-08-22 Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy Stroud, Matthew J. Biophys Rev Review The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a functional LINC complex is highlighted by the large number of mutations in genes encoding LINC complex proteins that lead to skeletal and cardiac myopathies. In this review, the structure, function, and interactions between components of the LINC complex will be described. Mutations that are known to cause cardiomyopathy in patients will be discussed alongside their respective mouse models. Furthermore, future challenges for the field and emerging technologies to investigate LINC complex function will be discussed. Springer Berlin Heidelberg 2018-06-04 /pmc/articles/PMC6082319/ /pubmed/29869195 http://dx.doi.org/10.1007/s12551-018-0431-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Stroud, Matthew J. Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title_full | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title_fullStr | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title_full_unstemmed | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title_short | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
title_sort | linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082319/ https://www.ncbi.nlm.nih.gov/pubmed/29869195 http://dx.doi.org/10.1007/s12551-018-0431-6 |
work_keys_str_mv | AT stroudmatthewj linkerofnucleoskeletonandcytoskeletoncomplexproteinsincardiomyopathy |