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Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy

The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a f...

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Detalles Bibliográficos
Autor principal: Stroud, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082319/
https://www.ncbi.nlm.nih.gov/pubmed/29869195
http://dx.doi.org/10.1007/s12551-018-0431-6
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author Stroud, Matthew J.
author_facet Stroud, Matthew J.
author_sort Stroud, Matthew J.
collection PubMed
description The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a functional LINC complex is highlighted by the large number of mutations in genes encoding LINC complex proteins that lead to skeletal and cardiac myopathies. In this review, the structure, function, and interactions between components of the LINC complex will be described. Mutations that are known to cause cardiomyopathy in patients will be discussed alongside their respective mouse models. Furthermore, future challenges for the field and emerging technologies to investigate LINC complex function will be discussed.
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spelling pubmed-60823192018-08-22 Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy Stroud, Matthew J. Biophys Rev Review The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a functional LINC complex is highlighted by the large number of mutations in genes encoding LINC complex proteins that lead to skeletal and cardiac myopathies. In this review, the structure, function, and interactions between components of the LINC complex will be described. Mutations that are known to cause cardiomyopathy in patients will be discussed alongside their respective mouse models. Furthermore, future challenges for the field and emerging technologies to investigate LINC complex function will be discussed. Springer Berlin Heidelberg 2018-06-04 /pmc/articles/PMC6082319/ /pubmed/29869195 http://dx.doi.org/10.1007/s12551-018-0431-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Stroud, Matthew J.
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title_full Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title_fullStr Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title_full_unstemmed Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title_short Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
title_sort linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082319/
https://www.ncbi.nlm.nih.gov/pubmed/29869195
http://dx.doi.org/10.1007/s12551-018-0431-6
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