Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach

The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recognize degenerate peptide motifs in a wide range of proteins, thereby recruiting such proteins and their complexes for scaffolding and/or poly(ADP-ribosyl)ation. Here, we pr...

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Detalles Bibliográficos
Autores principales: Pollock, Katie, Ranes, Michael, Collins, Ian, Guettler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer New York 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082341/
https://www.ncbi.nlm.nih.gov/pubmed/28695526
http://dx.doi.org/10.1007/978-1-4939-6993-7_28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082341/
https://www.ncbi.nlm.nih.gov/pubmed/28695526
http://dx.doi.org/10.1007/978-1-4939-6993-7_28

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