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Relationships between estimated autozygosity and complex traits in the UK Biobank

Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that are recessive with respect to fitness. Until rec...

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Detalles Bibliográficos
Autores principales:	Johnson, Emma C., Evans, Luke M., Keller, Matthew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082573/ https://www.ncbi.nlm.nih.gov/pubmed/30052639 http://dx.doi.org/10.1371/journal.pgen.1007556

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