Microglial pannexin-1 channel activation is a spinal determinant of joint pain

Chronic joint pain such as mechanical allodynia is the most debilitating symptom of arthritis, yet effective therapies are lacking. We identify the pannexin-1 (Panx1) channel as a therapeutic target for alleviating mechanical allodynia, a cardinal sign of arthritis. In rats, joint pain caused by int...

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Detalles Bibliográficos
Autores principales: Mousseau, Michael, Burma, Nicole E., Lee, Kwan Yeop, Leduc-Pessah, Heather, Kwok, Charlie H. T., Reid, Allison R., O’Brien, Melissa, Sagalajev, Boriss, Stratton, Jo Anne, Patrick, Natalya, Stemkowski, Patrick L., Biernaskie, Jeff, Zamponi, Gerald W., Salo, Paul, McDougall, Jason J., Prescott, Steven A., Matyas, John R., Trang, Tuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082646/
https://www.ncbi.nlm.nih.gov/pubmed/30101191
http://dx.doi.org/10.1126/sciadv.aas9846

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