Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TL...

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Detalles Bibliográficos
Autores principales: Lee, Sung-Bau, Segura-Bayona, Sandra, Villamor-Payà, Marina, Saredi, Giulia, Todd, Matthew A. M., Attolini, Camille Stephan-Otto, Chang, Ting-Yu, Stracker, Travis H., Groth, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082654/
https://www.ncbi.nlm.nih.gov/pubmed/30101194
http://dx.doi.org/10.1126/sciadv.aat4985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082654/
https://www.ncbi.nlm.nih.gov/pubmed/30101194
http://dx.doi.org/10.1126/sciadv.aat4985

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