Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates

Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of i...

Descripción completa

Detalles Bibliográficos
Autores principales: Dudley, Dawn M., Van Rompay, Koen K., Coffey, Lark L., Ardeshir, Amir, Keesler, Rebekah I., Grigsby, Peta L., Steinbach, Rosemary J., Hirsch, Alec J., MacAllister, Rhonda P., Hodge, Travis, Streblow, Daniel N., Tardif, Suzette, Patterson, Jean L., Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M., Martín, Claudia Sánchez-San, Chiu, Charles Y., Panganiban, Antonito T., Veazey, Ronald S., Wang, Xiaolei, Maness, Nicholas J., Gilbert, Margaret H., Bohm, Rudolf P., Adams Waldorf, Kristina M., Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E., Mohr, Emma L., Capuano, Saverio V., Friedrich, Thomas C., Golos, Thaddeus G., O'Connor, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082723/
https://www.ncbi.nlm.nih.gov/pubmed/29967348
http://dx.doi.org/10.1038/s41591-018-0088-5
Descripción
Sumario:Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Ejemplares similares