Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates

Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of i...

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Autores principales: Dudley, Dawn M., Van Rompay, Koen K., Coffey, Lark L., Ardeshir, Amir, Keesler, Rebekah I., Grigsby, Peta L., Steinbach, Rosemary J., Hirsch, Alec J., MacAllister, Rhonda P., Hodge, Travis, Streblow, Daniel N., Tardif, Suzette, Patterson, Jean L., Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M., Martín, Claudia Sánchez-San, Chiu, Charles Y., Panganiban, Antonito T., Veazey, Ronald S., Wang, Xiaolei, Maness, Nicholas J., Gilbert, Margaret H., Bohm, Rudolf P., Adams Waldorf, Kristina M., Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E., Mohr, Emma L., Capuano, Saverio V., Friedrich, Thomas C., Golos, Thaddeus G., O'Connor, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082723/
https://www.ncbi.nlm.nih.gov/pubmed/29967348
http://dx.doi.org/10.1038/s41591-018-0088-5
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author Dudley, Dawn M.
Van Rompay, Koen K.
Coffey, Lark L.
Ardeshir, Amir
Keesler, Rebekah I.
Grigsby, Peta L.
Steinbach, Rosemary J.
Hirsch, Alec J.
MacAllister, Rhonda P.
Hodge, Travis
Streblow, Daniel N.
Tardif, Suzette
Patterson, Jean L.
Tamhankar, Manasi
Seferovic, Maxim
Aagaard, Kjersti M.
Martín, Claudia Sánchez-San
Chiu, Charles Y.
Panganiban, Antonito T.
Veazey, Ronald S.
Wang, Xiaolei
Maness, Nicholas J.
Gilbert, Margaret H.
Bohm, Rudolf P.
Adams Waldorf, Kristina M.
Gale, Michael
Rajagopal, Lakshmi
Hotchkiss, Charlotte E.
Mohr, Emma L.
Capuano, Saverio V.
Friedrich, Thomas C.
Golos, Thaddeus G.
O'Connor, David H.
author_facet Dudley, Dawn M.
Van Rompay, Koen K.
Coffey, Lark L.
Ardeshir, Amir
Keesler, Rebekah I.
Grigsby, Peta L.
Steinbach, Rosemary J.
Hirsch, Alec J.
MacAllister, Rhonda P.
Hodge, Travis
Streblow, Daniel N.
Tardif, Suzette
Patterson, Jean L.
Tamhankar, Manasi
Seferovic, Maxim
Aagaard, Kjersti M.
Martín, Claudia Sánchez-San
Chiu, Charles Y.
Panganiban, Antonito T.
Veazey, Ronald S.
Wang, Xiaolei
Maness, Nicholas J.
Gilbert, Margaret H.
Bohm, Rudolf P.
Adams Waldorf, Kristina M.
Gale, Michael
Rajagopal, Lakshmi
Hotchkiss, Charlotte E.
Mohr, Emma L.
Capuano, Saverio V.
Friedrich, Thomas C.
Golos, Thaddeus G.
O'Connor, David H.
author_sort Dudley, Dawn M.
collection PubMed
description Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
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spelling pubmed-60827232019-01-02 Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates Dudley, Dawn M. Van Rompay, Koen K. Coffey, Lark L. Ardeshir, Amir Keesler, Rebekah I. Grigsby, Peta L. Steinbach, Rosemary J. Hirsch, Alec J. MacAllister, Rhonda P. Hodge, Travis Streblow, Daniel N. Tardif, Suzette Patterson, Jean L. Tamhankar, Manasi Seferovic, Maxim Aagaard, Kjersti M. Martín, Claudia Sánchez-San Chiu, Charles Y. Panganiban, Antonito T. Veazey, Ronald S. Wang, Xiaolei Maness, Nicholas J. Gilbert, Margaret H. Bohm, Rudolf P. Adams Waldorf, Kristina M. Gale, Michael Rajagopal, Lakshmi Hotchkiss, Charlotte E. Mohr, Emma L. Capuano, Saverio V. Friedrich, Thomas C. Golos, Thaddeus G. O'Connor, David H. Nat Med Article Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection. 2018-07-02 2018-08 /pmc/articles/PMC6082723/ /pubmed/29967348 http://dx.doi.org/10.1038/s41591-018-0088-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Dudley, Dawn M.
Van Rompay, Koen K.
Coffey, Lark L.
Ardeshir, Amir
Keesler, Rebekah I.
Grigsby, Peta L.
Steinbach, Rosemary J.
Hirsch, Alec J.
MacAllister, Rhonda P.
Hodge, Travis
Streblow, Daniel N.
Tardif, Suzette
Patterson, Jean L.
Tamhankar, Manasi
Seferovic, Maxim
Aagaard, Kjersti M.
Martín, Claudia Sánchez-San
Chiu, Charles Y.
Panganiban, Antonito T.
Veazey, Ronald S.
Wang, Xiaolei
Maness, Nicholas J.
Gilbert, Margaret H.
Bohm, Rudolf P.
Adams Waldorf, Kristina M.
Gale, Michael
Rajagopal, Lakshmi
Hotchkiss, Charlotte E.
Mohr, Emma L.
Capuano, Saverio V.
Friedrich, Thomas C.
Golos, Thaddeus G.
O'Connor, David H.
Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title_full Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title_fullStr Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title_full_unstemmed Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title_short Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
title_sort miscarriage and stillbirth following maternal zika virus infection in nonhuman primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082723/
https://www.ncbi.nlm.nih.gov/pubmed/29967348
http://dx.doi.org/10.1038/s41591-018-0088-5
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