A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy

Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that...

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Autores principales: Yang, Letao, Chueng, Sy-Tsong Dean, Li, Ying, Patel, Misaal, Rathnam, Christopher, Dey, Gangotri, Wang, Lu, Cai, Li, Lee, Ki-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082841/
https://www.ncbi.nlm.nih.gov/pubmed/30089775
http://dx.doi.org/10.1038/s41467-018-05599-2
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author Yang, Letao
Chueng, Sy-Tsong Dean
Li, Ying
Patel, Misaal
Rathnam, Christopher
Dey, Gangotri
Wang, Lu
Cai, Li
Lee, Ki-Bum
author_facet Yang, Letao
Chueng, Sy-Tsong Dean
Li, Ying
Patel, Misaal
Rathnam, Christopher
Dey, Gangotri
Wang, Lu
Cai, Li
Lee, Ki-Bum
author_sort Yang, Letao
collection PubMed
description Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that mimic the natural tissue microenvironment to deliver physical and soluble cues. However, several significant obstacles including burst release of drugs, insufficient cellular adhesion support, and slow scaffold degradation rate remain to be overcome before the full potential of bioscaffold–based stem-cell therapies can be realized. To this end, we developed a biodegradable nanoscaffold-based method for enhanced stem cell transplantation, differentiation, and drug delivery. These findings collectively support the therapeutic potential of our biodegradable hybrid inorganic (BHI) nanoscaffolds for advanced stem cell transplantation and neural tissue engineering.
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spelling pubmed-60828412018-08-10 A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy Yang, Letao Chueng, Sy-Tsong Dean Li, Ying Patel, Misaal Rathnam, Christopher Dey, Gangotri Wang, Lu Cai, Li Lee, Ki-Bum Nat Commun Article Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that mimic the natural tissue microenvironment to deliver physical and soluble cues. However, several significant obstacles including burst release of drugs, insufficient cellular adhesion support, and slow scaffold degradation rate remain to be overcome before the full potential of bioscaffold–based stem-cell therapies can be realized. To this end, we developed a biodegradable nanoscaffold-based method for enhanced stem cell transplantation, differentiation, and drug delivery. These findings collectively support the therapeutic potential of our biodegradable hybrid inorganic (BHI) nanoscaffolds for advanced stem cell transplantation and neural tissue engineering. Nature Publishing Group UK 2018-08-08 /pmc/articles/PMC6082841/ /pubmed/30089775 http://dx.doi.org/10.1038/s41467-018-05599-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Letao
Chueng, Sy-Tsong Dean
Li, Ying
Patel, Misaal
Rathnam, Christopher
Dey, Gangotri
Wang, Lu
Cai, Li
Lee, Ki-Bum
A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title_full A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title_fullStr A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title_full_unstemmed A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title_short A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
title_sort biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082841/
https://www.ncbi.nlm.nih.gov/pubmed/30089775
http://dx.doi.org/10.1038/s41467-018-05599-2
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