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A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis
Background: Power spectral density (PSD) analysis of the heartbeat intervals in the three main frequency bands [very low frequency (VLF), low frequency (LF), and high frequency (HF)] provides a quantitative non-invasive tool for assessing the function of the cardiovascular control system. In humans,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083004/ https://www.ncbi.nlm.nih.gov/pubmed/30116198 http://dx.doi.org/10.3389/fphys.2018.01001 |
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author | Behar, Joachim A. Rosenberg, Aviv A. Shemla, Ori Murphy, Kevin R. Koren, Gideon Billman, George E. Yaniv, Yael |
author_facet | Behar, Joachim A. Rosenberg, Aviv A. Shemla, Ori Murphy, Kevin R. Koren, Gideon Billman, George E. Yaniv, Yael |
author_sort | Behar, Joachim A. |
collection | PubMed |
description | Background: Power spectral density (PSD) analysis of the heartbeat intervals in the three main frequency bands [very low frequency (VLF), low frequency (LF), and high frequency (HF)] provides a quantitative non-invasive tool for assessing the function of the cardiovascular control system. In humans, these frequency bands were standardized following years of empirical evidence. However, no quantitative approach has justified the frequency cutoffs of these bands and how they might be adapted to other mammals. Defining mammal-specific frequency bands is necessary if the PSD analysis of the HR is to be used as a proxy for measuring the autonomic nervous system activity in animal models. Methods: We first describe the distribution of prominent frequency peaks found in the normalized PSD of mammalian data using a Gaussian mixture model while assuming three components corresponding to the traditional VLF, LF and HF bands. We trained the algorithm on a database of human electrocardiogram recordings (n = 18) and validated it on databases of dogs (n = 17) and mice (n = 8). Finally, we tested it to predict the bands for rabbits (n = 4) for the first time. Results: Double-logarithmic analysis demonstrates a scaling law between the GMM-identified cutoff frequencies and the typical heart rate (HR(m)): f(VLF-LF) = 0.0037⋅ [Formula: see text] , f(LF-HF) = 0.0017⋅ [Formula: see text] and f(HFup) = 0.0128⋅ [Formula: see text]. We found that the band cutoff frequencies and Gaussian mean scale with a power law of 1/4 or 1/8 of the typical body mass (BM(m)), thus revealing allometric power laws. Conclusion: Our automated data-driven approach allowed us to define the frequency bands in PSD analysis of beat-to-beat time series from different mammals. The scaling law between the band frequency cutoffs and the HR(m) can be used to approximate the PSD bands in other mammals. |
format | Online Article Text |
id | pubmed-6083004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60830042018-08-16 A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis Behar, Joachim A. Rosenberg, Aviv A. Shemla, Ori Murphy, Kevin R. Koren, Gideon Billman, George E. Yaniv, Yael Front Physiol Physiology Background: Power spectral density (PSD) analysis of the heartbeat intervals in the three main frequency bands [very low frequency (VLF), low frequency (LF), and high frequency (HF)] provides a quantitative non-invasive tool for assessing the function of the cardiovascular control system. In humans, these frequency bands were standardized following years of empirical evidence. However, no quantitative approach has justified the frequency cutoffs of these bands and how they might be adapted to other mammals. Defining mammal-specific frequency bands is necessary if the PSD analysis of the HR is to be used as a proxy for measuring the autonomic nervous system activity in animal models. Methods: We first describe the distribution of prominent frequency peaks found in the normalized PSD of mammalian data using a Gaussian mixture model while assuming three components corresponding to the traditional VLF, LF and HF bands. We trained the algorithm on a database of human electrocardiogram recordings (n = 18) and validated it on databases of dogs (n = 17) and mice (n = 8). Finally, we tested it to predict the bands for rabbits (n = 4) for the first time. Results: Double-logarithmic analysis demonstrates a scaling law between the GMM-identified cutoff frequencies and the typical heart rate (HR(m)): f(VLF-LF) = 0.0037⋅ [Formula: see text] , f(LF-HF) = 0.0017⋅ [Formula: see text] and f(HFup) = 0.0128⋅ [Formula: see text]. We found that the band cutoff frequencies and Gaussian mean scale with a power law of 1/4 or 1/8 of the typical body mass (BM(m)), thus revealing allometric power laws. Conclusion: Our automated data-driven approach allowed us to define the frequency bands in PSD analysis of beat-to-beat time series from different mammals. The scaling law between the band frequency cutoffs and the HR(m) can be used to approximate the PSD bands in other mammals. Frontiers Media S.A. 2018-08-02 /pmc/articles/PMC6083004/ /pubmed/30116198 http://dx.doi.org/10.3389/fphys.2018.01001 Text en Copyright © 2018 Behar, Rosenberg, Shemla, Murphy, Koren, Billman and Yaniv. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Behar, Joachim A. Rosenberg, Aviv A. Shemla, Ori Murphy, Kevin R. Koren, Gideon Billman, George E. Yaniv, Yael A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title | A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title_full | A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title_fullStr | A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title_full_unstemmed | A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title_short | A Universal Scaling Relation for Defining Power Spectral Bands in Mammalian Heart Rate Variability Analysis |
title_sort | universal scaling relation for defining power spectral bands in mammalian heart rate variability analysis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083004/ https://www.ncbi.nlm.nih.gov/pubmed/30116198 http://dx.doi.org/10.3389/fphys.2018.01001 |
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