Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Recent Zika virus (ZIKV) epidemics necessitate the urgent development of effective drugs and vaccines, which can be accelerated by an enhanced understanding of ZIKV biology. One of the ZIKV structural proteins, precursor membrane (prM), plays an important role in the assembly of mature virions throu...

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Autores principales: Nambala, Peter, Su, Wen-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083217/
https://www.ncbi.nlm.nih.gov/pubmed/30116235
http://dx.doi.org/10.3389/fmicb.2018.01797
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author Nambala, Peter
Su, Wen-Chi
author_facet Nambala, Peter
Su, Wen-Chi
author_sort Nambala, Peter
collection PubMed
description Recent Zika virus (ZIKV) epidemics necessitate the urgent development of effective drugs and vaccines, which can be accelerated by an enhanced understanding of ZIKV biology. One of the ZIKV structural proteins, precursor membrane (prM), plays an important role in the assembly of mature virions through cleavage of prM into M protein. Recent studies have suggested that prM protein might be implicated in the neurovirulence of ZIKV. Most vaccines targeting ZIKV include prM as the immunogen. Here, we review progress in our understanding of ZIKV prM protein and its application in ZIKV vaccine development.
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spelling pubmed-60832172018-08-16 Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development Nambala, Peter Su, Wen-Chi Front Microbiol Microbiology Recent Zika virus (ZIKV) epidemics necessitate the urgent development of effective drugs and vaccines, which can be accelerated by an enhanced understanding of ZIKV biology. One of the ZIKV structural proteins, precursor membrane (prM), plays an important role in the assembly of mature virions through cleavage of prM into M protein. Recent studies have suggested that prM protein might be implicated in the neurovirulence of ZIKV. Most vaccines targeting ZIKV include prM as the immunogen. Here, we review progress in our understanding of ZIKV prM protein and its application in ZIKV vaccine development. Frontiers Media S.A. 2018-08-02 /pmc/articles/PMC6083217/ /pubmed/30116235 http://dx.doi.org/10.3389/fmicb.2018.01797 Text en Copyright © 2018 Nambala and Su. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Nambala, Peter
Su, Wen-Chi
Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title_full Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title_fullStr Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title_full_unstemmed Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title_short Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development
title_sort role of zika virus prm protein in viral pathogenicity and use in vaccine development
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083217/
https://www.ncbi.nlm.nih.gov/pubmed/30116235
http://dx.doi.org/10.3389/fmicb.2018.01797
work_keys_str_mv AT nambalapeter roleofzikavirusprmproteininviralpathogenicityanduseinvaccinedevelopment
AT suwenchi roleofzikavirusprmproteininviralpathogenicityanduseinvaccinedevelopment

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