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Biologically Targeted Magnetic Hyperthermia: Potential and Limitations
Hyperthermia, the mild elevation of temperature to 40–43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treatment modality has been restricted by its inability to effectively and preferenti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083434/ https://www.ncbi.nlm.nih.gov/pubmed/30116191 http://dx.doi.org/10.3389/fphar.2018.00831 |
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author | Chang, David Lim, May Goos, Jeroen A. C. M. Qiao, Ruirui Ng, Yun Yee Mansfeld, Friederike M. Jackson, Michael Davis, Thomas P. Kavallaris, Maria |
author_facet | Chang, David Lim, May Goos, Jeroen A. C. M. Qiao, Ruirui Ng, Yun Yee Mansfeld, Friederike M. Jackson, Michael Davis, Thomas P. Kavallaris, Maria |
author_sort | Chang, David |
collection | PubMed |
description | Hyperthermia, the mild elevation of temperature to 40–43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treatment modality has been restricted by its inability to effectively and preferentially heat malignant cells. The limited spatial resolution may be circumvented by the intravenous administration of cancer-targeting magnetic nanoparticles that accumulate in the tumor, followed by the application of an alternating magnetic field to raise the temperature of the nanoparticles located in the tumor tissue. This targeted approach enables preferential heating of malignant cancer cells whilst sparing the surrounding normal tissue, potentially improving the effectiveness and safety of hyperthermia. Despite promising results in preclinical studies, there are numerous challenges that must be addressed before this technique can progress to the clinic. This review discusses these challenges and highlights the current understanding of targeted magnetic hyperthermia. |
format | Online Article Text |
id | pubmed-6083434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60834342018-08-16 Biologically Targeted Magnetic Hyperthermia: Potential and Limitations Chang, David Lim, May Goos, Jeroen A. C. M. Qiao, Ruirui Ng, Yun Yee Mansfeld, Friederike M. Jackson, Michael Davis, Thomas P. Kavallaris, Maria Front Pharmacol Pharmacology Hyperthermia, the mild elevation of temperature to 40–43°C, can induce cancer cell death and enhance the effects of radiotherapy and chemotherapy. However, achievement of its full potential as a clinically relevant treatment modality has been restricted by its inability to effectively and preferentially heat malignant cells. The limited spatial resolution may be circumvented by the intravenous administration of cancer-targeting magnetic nanoparticles that accumulate in the tumor, followed by the application of an alternating magnetic field to raise the temperature of the nanoparticles located in the tumor tissue. This targeted approach enables preferential heating of malignant cancer cells whilst sparing the surrounding normal tissue, potentially improving the effectiveness and safety of hyperthermia. Despite promising results in preclinical studies, there are numerous challenges that must be addressed before this technique can progress to the clinic. This review discusses these challenges and highlights the current understanding of targeted magnetic hyperthermia. Frontiers Media S.A. 2018-08-02 /pmc/articles/PMC6083434/ /pubmed/30116191 http://dx.doi.org/10.3389/fphar.2018.00831 Text en Copyright © 2018 Chang, Lim, Goos, Qiao, Ng, Mansfeld, Jackson, Davis and Kavallaris. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Chang, David Lim, May Goos, Jeroen A. C. M. Qiao, Ruirui Ng, Yun Yee Mansfeld, Friederike M. Jackson, Michael Davis, Thomas P. Kavallaris, Maria Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title | Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title_full | Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title_fullStr | Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title_full_unstemmed | Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title_short | Biologically Targeted Magnetic Hyperthermia: Potential and Limitations |
title_sort | biologically targeted magnetic hyperthermia: potential and limitations |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083434/ https://www.ncbi.nlm.nih.gov/pubmed/30116191 http://dx.doi.org/10.3389/fphar.2018.00831 |
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