Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review

Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocili...

Descripción completa

Detalles Bibliográficos
Autores principales: Ikeuchi, Hidekazu, Koinuma, Kana, Nakasatomi, Masao, Sakairi, Toru, Kaneko, Yoriaki, Maeshima, Akito, Yamazaki, Yuichi, Okamoto, Hiroaki, Mimura, Toshihide, Mochida, Satoshi, Nojima, Yoshihisa, Hiromura, Keiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083553/
https://www.ncbi.nlm.nih.gov/pubmed/30147981
http://dx.doi.org/10.1155/2018/6873276
_version_ 1783345998512259072
author Ikeuchi, Hidekazu
Koinuma, Kana
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Yamazaki, Yuichi
Okamoto, Hiroaki
Mimura, Toshihide
Mochida, Satoshi
Nojima, Yoshihisa
Hiromura, Keiju
author_facet Ikeuchi, Hidekazu
Koinuma, Kana
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Yamazaki, Yuichi
Okamoto, Hiroaki
Mimura, Toshihide
Mochida, Satoshi
Nojima, Yoshihisa
Hiromura, Keiju
author_sort Ikeuchi, Hidekazu
collection PubMed
description Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Analysis of serially stocked serum samples confirmed that hepatitis was caused by primary infection with HEV and not by viral reactivation. Her liver function improved after discontinuing tocilizumab and remained within the normal range without reactivation of HEV for >5 years after restarting tocilizumab. We also reviewed the published cases of hepatitis E that developed during RA treatment.
format Online
Article
Text
id pubmed-6083553
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60835532018-08-26 Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review Ikeuchi, Hidekazu Koinuma, Kana Nakasatomi, Masao Sakairi, Toru Kaneko, Yoriaki Maeshima, Akito Yamazaki, Yuichi Okamoto, Hiroaki Mimura, Toshihide Mochida, Satoshi Nojima, Yoshihisa Hiromura, Keiju Case Rep Rheumatol Case Report Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Analysis of serially stocked serum samples confirmed that hepatitis was caused by primary infection with HEV and not by viral reactivation. Her liver function improved after discontinuing tocilizumab and remained within the normal range without reactivation of HEV for >5 years after restarting tocilizumab. We also reviewed the published cases of hepatitis E that developed during RA treatment. Hindawi 2018-07-26 /pmc/articles/PMC6083553/ /pubmed/30147981 http://dx.doi.org/10.1155/2018/6873276 Text en Copyright © 2018 Hidekazu Ikeuchi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ikeuchi, Hidekazu
Koinuma, Kana
Nakasatomi, Masao
Sakairi, Toru
Kaneko, Yoriaki
Maeshima, Akito
Yamazaki, Yuichi
Okamoto, Hiroaki
Mimura, Toshihide
Mochida, Satoshi
Nojima, Yoshihisa
Hiromura, Keiju
Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title_full Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title_fullStr Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title_full_unstemmed Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title_short Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
title_sort hepatitis e during tocilizumab therapy in a patient with rheumatoid arthritis: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083553/
https://www.ncbi.nlm.nih.gov/pubmed/30147981
http://dx.doi.org/10.1155/2018/6873276
work_keys_str_mv AT ikeuchihidekazu hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT koinumakana hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT nakasatomimasao hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT sakairitoru hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT kanekoyoriaki hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT maeshimaakito hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT yamazakiyuichi hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT okamotohiroaki hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT mimuratoshihide hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT mochidasatoshi hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT nojimayoshihisa hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview
AT hiromurakeiju hepatitiseduringtocilizumabtherapyinapatientwithrheumatoidarthritiscasereportandliteraturereview

Ejemplares similares