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Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism

Children with ASD often exhibit early difficulties with action imitation, possibly due to low-level sensory or motor impairments. Impaired cortical rhythms have been demonstrated in adults with ASD during motor imitation. While those oscillations reflect an age-dependent process, they have not been...

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Autores principales: Buard, I., Kronberg, E., Steinmetz, S., Hepburn, S., Rojas, D. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083595/
https://www.ncbi.nlm.nih.gov/pubmed/30147953
http://dx.doi.org/10.1155/2018/9035793
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author Buard, I.
Kronberg, E.
Steinmetz, S.
Hepburn, S.
Rojas, D. C.
author_facet Buard, I.
Kronberg, E.
Steinmetz, S.
Hepburn, S.
Rojas, D. C.
author_sort Buard, I.
collection PubMed
description Children with ASD often exhibit early difficulties with action imitation, possibly due to low-level sensory or motor impairments. Impaired cortical rhythms have been demonstrated in adults with ASD during motor imitation. While those oscillations reflect an age-dependent process, they have not been fully investigated in youth with ASD. We collected magnetoencephalography data to examine patterns of oscillatory activity in the mu (8-13 Hz) and beta frequency (15-30 Hz) range in 14 adolescents with and 14 adolescents without ASD during a fine motor imitation task. Typically developing adolescents exhibited adult-like patterns of motor signals, e.g., event-related beta and mu desynchronization (ERD) before and during the movement and a postmovement beta rebound (PMBR) after the movement. In contrast, those with ASD exhibited stronger beta and mu-ERD and reduced PMBR. Behavioral performance was similar between groups despite differences in motor cortical oscillations. Finally, we observed age-related increases in PBMR and beta-ERD in the typically developing children, but this correlation was not present in the autism group. These results suggest reduced inhibitory drive in cortical rhythms in youth with autism during intact motor imitation. Furthermore, impairments in motor brain signals in autism may not be due to delayed brain development. In the context of the excitation-inhibition imbalance perspectives of autism, we offer new insights into altered organization of neurophysiological networks.
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spelling pubmed-60835952018-08-26 Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism Buard, I. Kronberg, E. Steinmetz, S. Hepburn, S. Rojas, D. C. Autism Res Treat Research Article Children with ASD often exhibit early difficulties with action imitation, possibly due to low-level sensory or motor impairments. Impaired cortical rhythms have been demonstrated in adults with ASD during motor imitation. While those oscillations reflect an age-dependent process, they have not been fully investigated in youth with ASD. We collected magnetoencephalography data to examine patterns of oscillatory activity in the mu (8-13 Hz) and beta frequency (15-30 Hz) range in 14 adolescents with and 14 adolescents without ASD during a fine motor imitation task. Typically developing adolescents exhibited adult-like patterns of motor signals, e.g., event-related beta and mu desynchronization (ERD) before and during the movement and a postmovement beta rebound (PMBR) after the movement. In contrast, those with ASD exhibited stronger beta and mu-ERD and reduced PMBR. Behavioral performance was similar between groups despite differences in motor cortical oscillations. Finally, we observed age-related increases in PBMR and beta-ERD in the typically developing children, but this correlation was not present in the autism group. These results suggest reduced inhibitory drive in cortical rhythms in youth with autism during intact motor imitation. Furthermore, impairments in motor brain signals in autism may not be due to delayed brain development. In the context of the excitation-inhibition imbalance perspectives of autism, we offer new insights into altered organization of neurophysiological networks. Hindawi 2018-07-25 /pmc/articles/PMC6083595/ /pubmed/30147953 http://dx.doi.org/10.1155/2018/9035793 Text en Copyright © 2018 I. Buard et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Buard, I.
Kronberg, E.
Steinmetz, S.
Hepburn, S.
Rojas, D. C.
Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title_full Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title_fullStr Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title_full_unstemmed Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title_short Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism
title_sort neuromagnetic beta-band oscillations during motor imitation in youth with autism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083595/
https://www.ncbi.nlm.nih.gov/pubmed/30147953
http://dx.doi.org/10.1155/2018/9035793
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