PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores

BACKGROUND: Polygenic risk scores (PRS) describe the genomic contribution to complex phenotypes and consistently account for a larger proportion of variance in outcome than single nucleotide polymorphisms (SNPs) alone. However, there is little consensus on the optimal data input for generating PRS,...

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Detalles Bibliográficos
Autores principales: Chen, Lawrence M., Yao, Nelson, Garg, Elika, Zhu, Yuecai, Nguyen, Thao T. T., Pokhvisneva, Irina, Hari Dass, Shantala A., Unternaehrer, Eva, Gaudreau, Hélène, Forest, Marie, McEwen, Lisa M., MacIsaac, Julia L., Kobor, Michael S., Greenwood, Celia M. T., Silveira, Patricia P., Meaney, Michael J., O’Donnell, Kieran J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083617/
https://www.ncbi.nlm.nih.gov/pubmed/30089455
http://dx.doi.org/10.1186/s12859-018-2289-9

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