Cargando…
Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study
New thiosemicarbazide-linked acridines 3a–c were prepared and investigated as chemosensors for the detection of biologically and environmentally important anions. The compounds 3a–c were found selective for fluoride (F(−)) with no affinity for other anions, i.e. (−)OAc, Br(−), I(−), HSO(4)(−), SO(4)...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society Publishing
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083729/ https://www.ncbi.nlm.nih.gov/pubmed/30109109 http://dx.doi.org/10.1098/rsos.180646 |
_version_ | 1783346039266213888 |
---|---|
author | Isaac, Ibanga Okon Munir, Iqra al-Rashida, Mariya Ali, Syed Abid Shafiq, Zahid Islam, Muhammad Ludwig, Ralf Ayub, Khurshid Khan, Khalid Mohammed Hameed, Abdul |
author_facet | Isaac, Ibanga Okon Munir, Iqra al-Rashida, Mariya Ali, Syed Abid Shafiq, Zahid Islam, Muhammad Ludwig, Ralf Ayub, Khurshid Khan, Khalid Mohammed Hameed, Abdul |
author_sort | Isaac, Ibanga Okon |
collection | PubMed |
description | New thiosemicarbazide-linked acridines 3a–c were prepared and investigated as chemosensors for the detection of biologically and environmentally important anions. The compounds 3a–c were found selective for fluoride (F(−)) with no affinity for other anions, i.e. (−)OAc, Br(−), I(−), HSO(4)(−), SO(4)(2−), PO(4)(3−), ClO(3)(−), ClO(4)(−), CN(−) and SCN(−). Further, upon the gradual addition of a fluoride anion (F(−)) source (tetrabutylammonium fluoride), a well-defined change in colour of the solution of probes 3a–c was observed. The anion-sensing process was studied in detail via UV–visible absorption, fluorescence and (1)H-NMR experiments. Moreover, during the synthesis of acridine probes 3a–c nickel fluoride (NiF(2)), a rarely explored transition metal fluoride salt, was used as the catalyst. Theoretical studies via density functional theory were also carried out to further investigate the sensing and anion (F(−)) selectivity pattern of these probes. |
format | Online Article Text |
id | pubmed-6083729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-60837292018-08-14 Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study Isaac, Ibanga Okon Munir, Iqra al-Rashida, Mariya Ali, Syed Abid Shafiq, Zahid Islam, Muhammad Ludwig, Ralf Ayub, Khurshid Khan, Khalid Mohammed Hameed, Abdul R Soc Open Sci Chemistry New thiosemicarbazide-linked acridines 3a–c were prepared and investigated as chemosensors for the detection of biologically and environmentally important anions. The compounds 3a–c were found selective for fluoride (F(−)) with no affinity for other anions, i.e. (−)OAc, Br(−), I(−), HSO(4)(−), SO(4)(2−), PO(4)(3−), ClO(3)(−), ClO(4)(−), CN(−) and SCN(−). Further, upon the gradual addition of a fluoride anion (F(−)) source (tetrabutylammonium fluoride), a well-defined change in colour of the solution of probes 3a–c was observed. The anion-sensing process was studied in detail via UV–visible absorption, fluorescence and (1)H-NMR experiments. Moreover, during the synthesis of acridine probes 3a–c nickel fluoride (NiF(2)), a rarely explored transition metal fluoride salt, was used as the catalyst. Theoretical studies via density functional theory were also carried out to further investigate the sensing and anion (F(−)) selectivity pattern of these probes. The Royal Society Publishing 2018-07-04 /pmc/articles/PMC6083729/ /pubmed/30109109 http://dx.doi.org/10.1098/rsos.180646 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Chemistry Isaac, Ibanga Okon Munir, Iqra al-Rashida, Mariya Ali, Syed Abid Shafiq, Zahid Islam, Muhammad Ludwig, Ralf Ayub, Khurshid Khan, Khalid Mohammed Hameed, Abdul Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title | Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title_full | Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title_fullStr | Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title_full_unstemmed | Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title_short | Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
title_sort | novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083729/ https://www.ncbi.nlm.nih.gov/pubmed/30109109 http://dx.doi.org/10.1098/rsos.180646 |
work_keys_str_mv | AT isaacibangaokon novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT muniriqra novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT alrashidamariya novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT alisyedabid novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT shafiqzahid novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT islammuhammad novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT ludwigralf novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT ayubkhurshid novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT khankhalidmohammed novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy AT hameedabdul novelacridinebasedthiosemicarbazonesasturnonchemosensorsforselectiverecognitionoffluorideanionaspectroscopicandtheoreticalstudy |