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Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review

Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use o...

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Autores principales: Albuquerque, Kamylla Rafaella Sena, Pacheco, Nívea Maria, del Rosario Loyo Casao, Thalia, de Melo, Fabiana Cristina Silveira Alves, Novaes, Rômulo Dias, Gonçalves, Reggiani Vilela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083739/
https://www.ncbi.nlm.nih.gov/pubmed/30147443
http://dx.doi.org/10.1155/2018/6797924
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author Albuquerque, Kamylla Rafaella Sena
Pacheco, Nívea Maria
del Rosario Loyo Casao, Thalia
de Melo, Fabiana Cristina Silveira Alves
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
author_facet Albuquerque, Kamylla Rafaella Sena
Pacheco, Nívea Maria
del Rosario Loyo Casao, Thalia
de Melo, Fabiana Cristina Silveira Alves
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
author_sort Albuquerque, Kamylla Rafaella Sena
collection PubMed
description Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use of natural products to treat this cancer. We performed a systematic review to compile the results of studies carried out in murine models and investigated the effect of plant extracts on melanoma treatment. Papers were selected in MEDLINE/Pubmed and Scopus according to the PRISM statement. Search filters were developed using three parameters: plant extract, melanoma, and animal model. The 35 identified studies were all submitted to the criteria described in the ARRIVE guidelines. The different extracts showed antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activity, and also proved to be effective in cell cycle modulation and apoptosis evasion. Bias analysis evidenced the absence of standardized experimental designs, as well as failures in statistical tests and in the presentation of results. The analysis of the studies suggests that the use of plant extracts is effective for the treatment of melanoma in murine models.
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spelling pubmed-60837392018-08-26 Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review Albuquerque, Kamylla Rafaella Sena Pacheco, Nívea Maria del Rosario Loyo Casao, Thalia de Melo, Fabiana Cristina Silveira Alves Novaes, Rômulo Dias Gonçalves, Reggiani Vilela Mediators Inflamm Review Article Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use of natural products to treat this cancer. We performed a systematic review to compile the results of studies carried out in murine models and investigated the effect of plant extracts on melanoma treatment. Papers were selected in MEDLINE/Pubmed and Scopus according to the PRISM statement. Search filters were developed using three parameters: plant extract, melanoma, and animal model. The 35 identified studies were all submitted to the criteria described in the ARRIVE guidelines. The different extracts showed antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activity, and also proved to be effective in cell cycle modulation and apoptosis evasion. Bias analysis evidenced the absence of standardized experimental designs, as well as failures in statistical tests and in the presentation of results. The analysis of the studies suggests that the use of plant extracts is effective for the treatment of melanoma in murine models. Hindawi 2018-07-26 /pmc/articles/PMC6083739/ /pubmed/30147443 http://dx.doi.org/10.1155/2018/6797924 Text en Copyright © 2018 Kamylla Rafaella Sena Albuquerque et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Albuquerque, Kamylla Rafaella Sena
Pacheco, Nívea Maria
del Rosario Loyo Casao, Thalia
de Melo, Fabiana Cristina Silveira Alves
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title_full Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title_fullStr Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title_full_unstemmed Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title_short Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
title_sort applicability of plant extracts in preclinical studies of melanoma: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083739/
https://www.ncbi.nlm.nih.gov/pubmed/30147443
http://dx.doi.org/10.1155/2018/6797924
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