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Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review
Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083739/ https://www.ncbi.nlm.nih.gov/pubmed/30147443 http://dx.doi.org/10.1155/2018/6797924 |
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author | Albuquerque, Kamylla Rafaella Sena Pacheco, Nívea Maria del Rosario Loyo Casao, Thalia de Melo, Fabiana Cristina Silveira Alves Novaes, Rômulo Dias Gonçalves, Reggiani Vilela |
author_facet | Albuquerque, Kamylla Rafaella Sena Pacheco, Nívea Maria del Rosario Loyo Casao, Thalia de Melo, Fabiana Cristina Silveira Alves Novaes, Rômulo Dias Gonçalves, Reggiani Vilela |
author_sort | Albuquerque, Kamylla Rafaella Sena |
collection | PubMed |
description | Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use of natural products to treat this cancer. We performed a systematic review to compile the results of studies carried out in murine models and investigated the effect of plant extracts on melanoma treatment. Papers were selected in MEDLINE/Pubmed and Scopus according to the PRISM statement. Search filters were developed using three parameters: plant extract, melanoma, and animal model. The 35 identified studies were all submitted to the criteria described in the ARRIVE guidelines. The different extracts showed antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activity, and also proved to be effective in cell cycle modulation and apoptosis evasion. Bias analysis evidenced the absence of standardized experimental designs, as well as failures in statistical tests and in the presentation of results. The analysis of the studies suggests that the use of plant extracts is effective for the treatment of melanoma in murine models. |
format | Online Article Text |
id | pubmed-6083739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60837392018-08-26 Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review Albuquerque, Kamylla Rafaella Sena Pacheco, Nívea Maria del Rosario Loyo Casao, Thalia de Melo, Fabiana Cristina Silveira Alves Novaes, Rômulo Dias Gonçalves, Reggiani Vilela Mediators Inflamm Review Article Melanoma is the most aggressive form of skin cancer and arises from melanocyte gene mutation. This disease is multifactorial, but its main cause is the excessive exposure to ultraviolet radiation. Currently, available chemotherapy has shown little expressive results, which may justify the high use of natural products to treat this cancer. We performed a systematic review to compile the results of studies carried out in murine models and investigated the effect of plant extracts on melanoma treatment. Papers were selected in MEDLINE/Pubmed and Scopus according to the PRISM statement. Search filters were developed using three parameters: plant extract, melanoma, and animal model. The 35 identified studies were all submitted to the criteria described in the ARRIVE guidelines. The different extracts showed antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activity, and also proved to be effective in cell cycle modulation and apoptosis evasion. Bias analysis evidenced the absence of standardized experimental designs, as well as failures in statistical tests and in the presentation of results. The analysis of the studies suggests that the use of plant extracts is effective for the treatment of melanoma in murine models. Hindawi 2018-07-26 /pmc/articles/PMC6083739/ /pubmed/30147443 http://dx.doi.org/10.1155/2018/6797924 Text en Copyright © 2018 Kamylla Rafaella Sena Albuquerque et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Albuquerque, Kamylla Rafaella Sena Pacheco, Nívea Maria del Rosario Loyo Casao, Thalia de Melo, Fabiana Cristina Silveira Alves Novaes, Rômulo Dias Gonçalves, Reggiani Vilela Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title | Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title_full | Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title_fullStr | Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title_full_unstemmed | Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title_short | Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review |
title_sort | applicability of plant extracts in preclinical studies of melanoma: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083739/ https://www.ncbi.nlm.nih.gov/pubmed/30147443 http://dx.doi.org/10.1155/2018/6797924 |
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