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Klotho and PPAR Gamma Activation Mediate the Renoprotective Effect of Losartan in the 5/6 Nephrectomy Model

Renin angiotensin system (RAS) blockade reduces the progression of chronic kidney disease (CKD) independently of its antihypertensive effect. Ang II-induced fibrosis can be mediated by molecules such as klotho, peroxisome proliferator-activate receptor γ (PPAR-γ), and the Wnt/β-catenin pathway; howe...

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Detalles Bibliográficos
Autores principales:	Maquigussa, Edgar, Paterno, Josne C., de Oliveira Pokorny, Gabriel H., da Silva Perez, Mariana, Varela, Vanessa A., da Silva Novaes, Antônio, Schor, Nestor, Boim, Mirian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084001/ https://www.ncbi.nlm.nih.gov/pubmed/30116202 http://dx.doi.org/10.3389/fphys.2018.01033

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