A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses

Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteri...

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Detalles Bibliográficos
Autor principal: Lara-Tejero, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2001
Materias:
Directions in Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084029/
https://www.ncbi.nlm.nih.gov/pubmed/12805665
http://dx.doi.org/10.1100/tsw.2001.27
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author Lara-Tejero, Maria
author_facet Lara-Tejero, Maria
author_sort Lara-Tejero, Maria
collection PubMed
description Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest [3]. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.
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spelling pubmed-60840292018-08-26 A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses Lara-Tejero, Maria ScientificWorldJournal Directions in Science Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest [3]. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive. TheScientificWorldJOURNAL 2001-05-01 /pmc/articles/PMC6084029/ /pubmed/12805665 http://dx.doi.org/10.1100/tsw.2001.27 Text en Copyright © 2001 Maria Lara-Tejero. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Directions in Science
Lara-Tejero, Maria
A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title_full A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title_fullStr A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title_full_unstemmed A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title_short A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
title_sort bacterial toxin that causes dna damage to modulate cellular responses
topic Directions in Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084029/
https://www.ncbi.nlm.nih.gov/pubmed/12805665
http://dx.doi.org/10.1100/tsw.2001.27
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