Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)

Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096B...

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Detalles Bibliográficos
Autores principales: Razzaque, Z., Shaw, D., Bock, M., Maskell, L., Pickard, J., Sirinathsinghji, D., Longmore, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2001
Materias:
Extended Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084166/
http://dx.doi.org/10.1100/tsw.2001.437
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author Razzaque, Z.
Shaw, D.
Bock, M.
Maskell, L.
Pickard, J.
Sirinathsinghji, D.
Longmore, J.
author_facet Razzaque, Z.
Shaw, D.
Bock, M.
Maskell, L.
Pickard, J.
Sirinathsinghji, D.
Longmore, J.
author_sort Razzaque, Z.
collection PubMed
description Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).
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spelling pubmed-60841662018-08-26 Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37) Razzaque, Z. Shaw, D. Bock, M. Maskell, L. Pickard, J. Sirinathsinghji, D. Longmore, J. ScientificWorldJournal Extended Abstract Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA). TheScientificWorldJOURNAL 2001-11-10 /pmc/articles/PMC6084166/ http://dx.doi.org/10.1100/tsw.2001.437 Text en Copyright © 2001 Z. Razzaque et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Extended Abstract
Razzaque, Z.
Shaw, D.
Bock, M.
Maskell, L.
Pickard, J.
Sirinathsinghji, D.
Longmore, J.
Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title_full Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title_fullStr Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title_full_unstemmed Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title_short Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
title_sort study of cgrp-receptors in human isolated middle meningeal arteries using bibn4096bs, compound 1, and hαcgrp(8-37)
topic Extended Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084166/
http://dx.doi.org/10.1100/tsw.2001.437
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