Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP

a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynt...

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Detalles Bibliográficos
Autores principales: Lee, Jongho, Emeson, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2001
Materias:
Extended Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084207/
http://dx.doi.org/10.1100/tsw.2001.423
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author Lee, Jongho
Emeson, Ronald B.
author_facet Lee, Jongho
Emeson, Ronald B.
author_sort Lee, Jongho
collection PubMed
description a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynthesis, nociception, and neurogenic inflammation), the precise physiological roles of CGRP remain to be elucidated. To provide a better understanding of the physiological role(s) mediated by this peptide neurotransmitter, we have generated aCGRP-null mice by targeted modification in embryonic stem cells.
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spelling pubmed-60842072018-08-26 Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP Lee, Jongho Emeson, Ronald B. ScientificWorldJournal Extended Abstract a-Calcitonin gene-related peptide (aCGRP) is a pleiotropic peptide neuromodulator that is widely expressed throughout the central and peripheral nervous systems. Although CGRP has been implicated in numerous physiological processes (including peripheral vasodilatation, acetylcholine receptor biosynthesis, nociception, and neurogenic inflammation), the precise physiological roles of CGRP remain to be elucidated. To provide a better understanding of the physiological role(s) mediated by this peptide neurotransmitter, we have generated aCGRP-null mice by targeted modification in embryonic stem cells. TheScientificWorldJOURNAL 2001-12-19 /pmc/articles/PMC6084207/ http://dx.doi.org/10.1100/tsw.2001.423 Text en Copyright © 2001 Jongho Lee and Ronald B. Emeson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Extended Abstract
Lee, Jongho
Emeson, Ronald B.
Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_full Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_fullStr Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_full_unstemmed Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_short Alterations in Neurogenic Inflammatory Responses in Mice Lacking αCGRP
title_sort alterations in neurogenic inflammatory responses in mice lacking αcgrp
topic Extended Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084207/
http://dx.doi.org/10.1100/tsw.2001.423
work_keys_str_mv AT leejongho alterationsinneurogenicinflammatoryresponsesinmicelackingacgrp
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