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miRNA engineering of CHO cells facilitates production of difficult‐to‐express proteins and increases success in cell line development
In recent years, coherent with growing biologics portfolios also the number of complex and thus difficult‐to‐express (DTE) therapeutic proteins has increased considerably. DTE proteins challenge bioprocess development and can include various therapeutic protein formats such as monoclonal antibodies...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084326/ https://www.ncbi.nlm.nih.gov/pubmed/28262952 http://dx.doi.org/10.1002/bit.26280 |