ONETOOL for the analysis of family-based big data

MOTIVATION: Despite the need for separate tools to analyze family-based data, there are only a handful of tools optimized for family-based big data compared to the number of tools available for analyzing population-based data. RESULTS: ONETOOL implements the properties of well-known existing family data analysis tools and recently developed methods in a computationally efficient manner, and so is suitable for analyzing the vast amount of variant data available from sequencing family members, providing a rich choice of analysis methods for big data on families. AVAILABILITY AND IMPLEMENTATION: ONETOOL is freely available from http://healthstat.snu.ac.kr/software/onetool/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.