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Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease

By using a 5-day forced swimming test (FS) that we previously developed, swim immobility was induced in 3xTg Alzheimer's model mice and wild-type (WT) mice. After the initial 5-day FS, the next and last swimming session was performed at a 4-week interval, during which the immobility was reduced...

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Autores principales: Luo, Xianwen, Shui, Yuan, Wang, Furong, Yamamoto, Ryo, Kato, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084821/
https://www.ncbi.nlm.nih.gov/pubmed/30135936
http://dx.doi.org/10.1016/j.ibror.2017.05.001
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author Luo, Xianwen
Shui, Yuan
Wang, Furong
Yamamoto, Ryo
Kato, Nobuo
author_facet Luo, Xianwen
Shui, Yuan
Wang, Furong
Yamamoto, Ryo
Kato, Nobuo
author_sort Luo, Xianwen
collection PubMed
description By using a 5-day forced swimming test (FS) that we previously developed, swim immobility was induced in 3xTg Alzheimer's model mice and wild-type (WT) mice. After the initial 5-day FS, the next and last swimming session was performed at a 4-week interval, during which the immobility was reduced in 3xTg mice, but was maintained fully in WT mice. After FS, context-dependent fear learning was normally induced in WT mice, but was impaired in 3xTg mice, suggesting that FS may exaggerate cognitive deficits typical to 3xTg mice. Hippocampal long-term potentiation (LTP) at Schaffer collateral-CA1 synapses was suppressed by FS in WT mice, but not in 3xTg mice, indicating that FS modifies LTP in the WT mouse hippocampus, but not in 3xTg tissue. FS increased excitability of cingulate cortex pyramidal cells similarly in WT and 3xTg mice. Agreeing with our previous finding that expression of Homer1a protein is decreased in the cingulate cortex in harmony with FS-induced immobility, western blot showed that Homer1a expression is reduced by FS in the WT mice. In 3xTg mice, by contrast, FS failed to reduce Homer1a expression. The disrupted endurance of FS-induced immobility in 3xTg mice appears to be attributable to impaired cognition typical to this genotype. Failure of FS to alter LTP magnitude might be related to unaltered Homer1a expression after FS in 3xTg mice.
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spelling pubmed-60848212018-08-22 Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease Luo, Xianwen Shui, Yuan Wang, Furong Yamamoto, Ryo Kato, Nobuo IBRO Rep Article By using a 5-day forced swimming test (FS) that we previously developed, swim immobility was induced in 3xTg Alzheimer's model mice and wild-type (WT) mice. After the initial 5-day FS, the next and last swimming session was performed at a 4-week interval, during which the immobility was reduced in 3xTg mice, but was maintained fully in WT mice. After FS, context-dependent fear learning was normally induced in WT mice, but was impaired in 3xTg mice, suggesting that FS may exaggerate cognitive deficits typical to 3xTg mice. Hippocampal long-term potentiation (LTP) at Schaffer collateral-CA1 synapses was suppressed by FS in WT mice, but not in 3xTg mice, indicating that FS modifies LTP in the WT mouse hippocampus, but not in 3xTg tissue. FS increased excitability of cingulate cortex pyramidal cells similarly in WT and 3xTg mice. Agreeing with our previous finding that expression of Homer1a protein is decreased in the cingulate cortex in harmony with FS-induced immobility, western blot showed that Homer1a expression is reduced by FS in the WT mice. In 3xTg mice, by contrast, FS failed to reduce Homer1a expression. The disrupted endurance of FS-induced immobility in 3xTg mice appears to be attributable to impaired cognition typical to this genotype. Failure of FS to alter LTP magnitude might be related to unaltered Homer1a expression after FS in 3xTg mice. Elsevier 2017-05-03 /pmc/articles/PMC6084821/ /pubmed/30135936 http://dx.doi.org/10.1016/j.ibror.2017.05.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Luo, Xianwen
Shui, Yuan
Wang, Furong
Yamamoto, Ryo
Kato, Nobuo
Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title_full Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title_fullStr Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title_full_unstemmed Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title_short Impaired retention of depression-like behavior in a mouse model of Alzheimer's disease
title_sort impaired retention of depression-like behavior in a mouse model of alzheimer's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084821/
https://www.ncbi.nlm.nih.gov/pubmed/30135936
http://dx.doi.org/10.1016/j.ibror.2017.05.001
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