Carcinogenesis in prostate cancer: The role of long non-coding RNAs

LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been re...

Descripción completa

Detalles Bibliográficos
Autores principales: Aird, John, Baird, Anne-Marie, Lim, Marvin C.J., McDermott, Ray, Finn, Stephen P., Gray, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084828/
https://www.ncbi.nlm.nih.gov/pubmed/30159437
http://dx.doi.org/10.1016/j.ncrna.2018.01.001
Descripción
Sumario:LncRNAs appear to play a considerable role in tumourigenesis through regulating key processes in cancer cells such as proliferative signalling, replicative immortality, invasion and metastasis, evasion of growth suppressors, induction of angiogenesis and resistance to apoptosis. LncRNAs have been reported to play a role in prostate cancer, particularly in regulating the androgen receptor signalling pathway. In this review article, we summarise the role of 34 lncRNAs in prostate cancer with a particular focus on their role in the androgen receptor signalling pathway and the epithelial to mesenchymal transition pathway.

Ejemplares similares