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Translational applications of microRNAs in cancer, and therapeutic implications
The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therap...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084838/ https://www.ncbi.nlm.nih.gov/pubmed/30159433 http://dx.doi.org/10.1016/j.ncrna.2017.12.002 |
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author | Kwok, Grace T. Zhao, Jing Ting Weiss, Jocelyn Mugridge, Nancy Brahmbhatt, Himanshu MacDiarmid, Jennifer A. Robinson, Bruce G. Sidhu, Stan B. |
author_facet | Kwok, Grace T. Zhao, Jing Ting Weiss, Jocelyn Mugridge, Nancy Brahmbhatt, Himanshu MacDiarmid, Jennifer A. Robinson, Bruce G. Sidhu, Stan B. |
author_sort | Kwok, Grace T. |
collection | PubMed |
description | The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers. |
format | Online Article Text |
id | pubmed-6084838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-60848382018-08-29 Translational applications of microRNAs in cancer, and therapeutic implications Kwok, Grace T. Zhao, Jing Ting Weiss, Jocelyn Mugridge, Nancy Brahmbhatt, Himanshu MacDiarmid, Jennifer A. Robinson, Bruce G. Sidhu, Stan B. Noncoding RNA Res Article The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers. KeAi Publishing 2017-12-20 /pmc/articles/PMC6084838/ /pubmed/30159433 http://dx.doi.org/10.1016/j.ncrna.2017.12.002 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Kwok, Grace T. Zhao, Jing Ting Weiss, Jocelyn Mugridge, Nancy Brahmbhatt, Himanshu MacDiarmid, Jennifer A. Robinson, Bruce G. Sidhu, Stan B. Translational applications of microRNAs in cancer, and therapeutic implications |
title | Translational applications of microRNAs in cancer, and therapeutic implications |
title_full | Translational applications of microRNAs in cancer, and therapeutic implications |
title_fullStr | Translational applications of microRNAs in cancer, and therapeutic implications |
title_full_unstemmed | Translational applications of microRNAs in cancer, and therapeutic implications |
title_short | Translational applications of microRNAs in cancer, and therapeutic implications |
title_sort | translational applications of micrornas in cancer, and therapeutic implications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084838/ https://www.ncbi.nlm.nih.gov/pubmed/30159433 http://dx.doi.org/10.1016/j.ncrna.2017.12.002 |
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