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Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation

Unsaturated omega-3 fatty acids, especially docosahexaenoic acid (DHA), when fed to dogs improves cognitive and neurological development. Supplementation with omega-3 fatty acids such as DHA and eicosapentaenoic acid (EPA) has also been associated with lipid peroxidation, which in turn has been impl...

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Autores principales: Oberbauer, A. M., Daniels, R., Levy, K., Famula, T. R., Mundell, P., Kelley, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084972/
https://www.ncbi.nlm.nih.gov/pubmed/30092106
http://dx.doi.org/10.1371/journal.pone.0202157
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author Oberbauer, A. M.
Daniels, R.
Levy, K.
Famula, T. R.
Mundell, P.
Kelley, R.
author_facet Oberbauer, A. M.
Daniels, R.
Levy, K.
Famula, T. R.
Mundell, P.
Kelley, R.
author_sort Oberbauer, A. M.
collection PubMed
description Unsaturated omega-3 fatty acids, especially docosahexaenoic acid (DHA), when fed to dogs improves cognitive and neurological development. Supplementation with omega-3 fatty acids such as DHA and eicosapentaenoic acid (EPA) has also been associated with lipid peroxidation, which in turn has been implicated in reduced body weight and altered bone formation. To assess the impact of omega-3 fatty acid supplementation on skeletal growth, diets containing three levels of DHA and EPA (0.01 and 0.01%, 0.14 and 0.12%, and 0.21 and 0.18%, respectively) were fed to bitches during gestation and lactation with puppies also supplemented through weaning. Thus, the subjects studied were the puppies supplemented with DHA and EPA through gestation and early postnatal life. The hip joint conformation of the puppies (n = 676) was recorded at adulthood using two radiographic, non-invasive evaluations. In this population, females had higher hip distraction indices (DI) than males. Males from the lower two levels of DHA and EPA supplementation had significantly smaller hip DI than all females and males from the highest DHA and EPA supplementation. In contrast, there were no diet effects on anatomical indicators of hip joint conformation and no visible arthritic changes. These data suggest that dietary supplementation of DHA and EPA during gestation and the perinatal period to weaning does not adversely influence hip joint formation of dogs.
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spelling pubmed-60849722018-08-18 Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation Oberbauer, A. M. Daniels, R. Levy, K. Famula, T. R. Mundell, P. Kelley, R. PLoS One Research Article Unsaturated omega-3 fatty acids, especially docosahexaenoic acid (DHA), when fed to dogs improves cognitive and neurological development. Supplementation with omega-3 fatty acids such as DHA and eicosapentaenoic acid (EPA) has also been associated with lipid peroxidation, which in turn has been implicated in reduced body weight and altered bone formation. To assess the impact of omega-3 fatty acid supplementation on skeletal growth, diets containing three levels of DHA and EPA (0.01 and 0.01%, 0.14 and 0.12%, and 0.21 and 0.18%, respectively) were fed to bitches during gestation and lactation with puppies also supplemented through weaning. Thus, the subjects studied were the puppies supplemented with DHA and EPA through gestation and early postnatal life. The hip joint conformation of the puppies (n = 676) was recorded at adulthood using two radiographic, non-invasive evaluations. In this population, females had higher hip distraction indices (DI) than males. Males from the lower two levels of DHA and EPA supplementation had significantly smaller hip DI than all females and males from the highest DHA and EPA supplementation. In contrast, there were no diet effects on anatomical indicators of hip joint conformation and no visible arthritic changes. These data suggest that dietary supplementation of DHA and EPA during gestation and the perinatal period to weaning does not adversely influence hip joint formation of dogs. Public Library of Science 2018-08-09 /pmc/articles/PMC6084972/ /pubmed/30092106 http://dx.doi.org/10.1371/journal.pone.0202157 Text en © 2018 Oberbauer et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Oberbauer, A. M.
Daniels, R.
Levy, K.
Famula, T. R.
Mundell, P.
Kelley, R.
Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title_full Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title_fullStr Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title_full_unstemmed Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title_short Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
title_sort maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084972/
https://www.ncbi.nlm.nih.gov/pubmed/30092106
http://dx.doi.org/10.1371/journal.pone.0202157
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