TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

The renin-angiotensin system (RAS), which plays an important role in the progression of heart failure, is efficiently blocked by the inhibition of renin, the rate-limiting enzyme in the RAS cascade. In the present study, we investigated the cardioprotective effects of TAK-272 (SCO-272, imarikiren),...

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Detalles Bibliográficos
Autores principales: Hara, Tomoya, Nishimura, Satoshi, Yamamoto, Toshihiro, Kajimoto, Yumiko, Kusumoto, Keiji, Kanagawa, Ray, Ikeda, Shota, Nishimoto, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084973/
https://www.ncbi.nlm.nih.gov/pubmed/30092100
http://dx.doi.org/10.1371/journal.pone.0202176

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