Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to cellular dysfunction or is protective is unknown...

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Detalles Bibliográficos
Autores principales: Duncan, Olivia F., Granat, Lucy, Ranganathan, Ramya, Singh, Vandana K., Mazaud, David, Fanto, Manolis, Chambers, David, Ballard, Clive G., Bateman, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085068/
https://www.ncbi.nlm.nih.gov/pubmed/30059502
http://dx.doi.org/10.1371/journal.pgen.1007567

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