Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT) accelerated type 1 diabetes (T1D) development in male NOD mice. The single course had deep and persistent effects on the intestinal microbiome,...

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Detalles Bibliográficos
Autores principales: Zhang, Xue-Song, Li, Jackie, Krautkramer, Kimberly A, Badri, Michelle, Battaglia, Thomas, Borbet, Timothy C, Koh, Hyunwook, Ng, Sandy, Sibley, Rachel A, Li, Yuanyuan, Pathmasiri, Wimal, Jindal, Shawn, Shields-Cutler, Robin R, Hillmann, Ben, Al-Ghalith, Gabriel A, Ruiz, Victoria E, Livanos, Alexandra, van ‘t Wout, Angélique B, Nagalingam, Nabeetha, Rogers, Arlin B, Sumner, Susan Jenkins, Knights, Dan, Denu, John M, Li, Huilin, Ruggles, Kelly V, Bonneau, Richard, Williamson, R Anthony, Rauch, Marcus, Blaser, Martin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085123/
https://www.ncbi.nlm.nih.gov/pubmed/30039798
http://dx.doi.org/10.7554/eLife.37816

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