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Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults
BACKGROUND: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals’ omega-3 status. We hypothesized that the...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085127/ https://www.ncbi.nlm.nih.gov/pubmed/29570511 http://dx.doi.org/10.1097/HJH.0000000000001728 |
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author | Filipovic, Mark G. Aeschbacher, Stefanie Reiner, Martin F. Stivala, Simona Gobbato, Sara Bonetti, Nicole Risch, Martin Risch, Lorenz Camici, Giovanni G. Luescher, Thomas F. von Schacky, Clemens Conen, David Beer, Juerg H. |
author_facet | Filipovic, Mark G. Aeschbacher, Stefanie Reiner, Martin F. Stivala, Simona Gobbato, Sara Bonetti, Nicole Risch, Martin Risch, Lorenz Camici, Giovanni G. Luescher, Thomas F. von Schacky, Clemens Conen, David Beer, Juerg H. |
author_sort | Filipovic, Mark G. |
collection | PubMed |
description | BACKGROUND: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals’ omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults. METHODS: The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25–41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m(2) were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders. RESULTS: Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was −2.67 mmHg (−4.83; −0.51; P = 0.02) and −2.30 mmHg (−3.92; −0.68; P = 0.005) for 24-h SBP and DBP, respectively. CONCLUSION: A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n − 3 FA may be a strategy for primary prevention of hypertension. |
format | Online Article Text |
id | pubmed-6085127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-60851272018-08-24 Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults Filipovic, Mark G. Aeschbacher, Stefanie Reiner, Martin F. Stivala, Simona Gobbato, Sara Bonetti, Nicole Risch, Martin Risch, Lorenz Camici, Giovanni G. Luescher, Thomas F. von Schacky, Clemens Conen, David Beer, Juerg H. J Hypertens ORIGINAL PAPERS: Lipids and blood pressure BACKGROUND: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n − 3 FA on BP in young, healthy adults remains unknown. The Omega-3 Index reliably reflects an individuals’ omega-3 status. We hypothesized that the Omega-3 Index is inversely associated with BP levels in young healthy adults. METHODS: The current study (n = 2036) is a cross-sectional study investigating the baseline characteristics of a cohort, which includes healthy adults, age 25–41 years. Individuals with cardiovascular disease, known diabetes or a BMI higher than 35 kg/m(2) were excluded. The Omega-3 Index was determined in whole blood using gas chromatography. Association with office and 24-h BP was assessed using multivariable linear regression models adjusted for potential confounders. RESULTS: Median Omega-3 Index was 4.58% (interquartile range 4.08; 5.25). Compared with individuals in the lowest Omega-3 Index quartile, individuals in the highest had a SBP and DBP that was 4 and 2 mmHg lower, respectively (P < 0.01). A significant linear inverse relationship of the Omega-3 Index with 24-h and office BP was observed. Per 1-U increase in log-transformed Omega-3 Index the lowering in BP (given as multivariable adjusted β coefficients; 95% confidence interval) was −2.67 mmHg (−4.83; −0.51; P = 0.02) and −2.30 mmHg (−3.92; −0.68; P = 0.005) for 24-h SBP and DBP, respectively. CONCLUSION: A higher Omega-3 Index is associated with statistically significant, clinically relevant lower SBP and DBP levels in normotensive young and healthy individuals. Diets rich in n − 3 FA may be a strategy for primary prevention of hypertension. Lippincott Williams & Wilkins 2018-07 2018-07-17 /pmc/articles/PMC6085127/ /pubmed/29570511 http://dx.doi.org/10.1097/HJH.0000000000001728 Text en Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. |
spellingShingle | ORIGINAL PAPERS: Lipids and blood pressure Filipovic, Mark G. Aeschbacher, Stefanie Reiner, Martin F. Stivala, Simona Gobbato, Sara Bonetti, Nicole Risch, Martin Risch, Lorenz Camici, Giovanni G. Luescher, Thomas F. von Schacky, Clemens Conen, David Beer, Juerg H. Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title | Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title_full | Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title_fullStr | Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title_full_unstemmed | Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title_short | Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
title_sort | whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults |
topic | ORIGINAL PAPERS: Lipids and blood pressure |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085127/ https://www.ncbi.nlm.nih.gov/pubmed/29570511 http://dx.doi.org/10.1097/HJH.0000000000001728 |
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