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Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls

INTRODUCTION: Gabapentin regulates pain processing by direct action on primary afferent nociceptors and dorsal horn nociresponsive neurons. Through an action at supraspinal levels, gabapentin also engages descending noradrenergic inhibitory controls that indirectly regulate spinal cord pain processi...

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Detalles Bibliográficos
Autores principales:	Juarez-Salinas, Dina L., Braz, Joao M., Hamel, Katherine A., Basbaum, Allan I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2018
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085145/ https://www.ncbi.nlm.nih.gov/pubmed/30123855 http://dx.doi.org/10.1097/PR9.0000000000000659

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