Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but their mechanisms of action and efficacy are not fully understood. ATRA inhibits leukemia, breast, and liver cancer by targeting isomerase Pin1, a master regulator of oncogenic s...

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Detalles Bibliográficos
Autores principales: Kozono, Shingo, Lin, Yu-Min, Seo, Hyuk-Soo, Pinch, Benika, Lian, Xiaolan, Qiu, Chenxi, Herbert, Megan K., Chen, Chun-Hau, Tan, Li, Gao, Ziang Jeff, Massefski, Walter, Doctor, Zainab M., Jackson, Brian P., Chen, Yuanzhong, Dhe-Paganon, Sirano, Lu, Kun Ping, Zhou, Xiao Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085299/
https://www.ncbi.nlm.nih.gov/pubmed/30093655
http://dx.doi.org/10.1038/s41467-018-05402-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085299/
https://www.ncbi.nlm.nih.gov/pubmed/30093655
http://dx.doi.org/10.1038/s41467-018-05402-2

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