Cargando…

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but their mechanisms of action and efficacy are not fully understood. ATRA inhibits leukemia, breast, and liver cancer by targeting isomerase Pin1, a master regulator of oncogenic s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kozono, Shingo, Lin, Yu-Min, Seo, Hyuk-Soo, Pinch, Benika, Lian, Xiaolan, Qiu, Chenxi, Herbert, Megan K., Chen, Chun-Hau, Tan, Li, Gao, Ziang Jeff, Massefski, Walter, Doctor, Zainab M., Jackson, Brian P., Chen, Yuanzhong, Dhe-Paganon, Sirano, Lu, Kun Ping, Zhou, Xiao Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085299/ https://www.ncbi.nlm.nih.gov/pubmed/30093655 http://dx.doi.org/10.1038/s41467-018-05402-2

Ejemplares similares

Identification of a potent and selective covalent Pin1 inhibitor
por: Pinch, Benika J., et al.
Publicado: (2020)

Oligomeric Structure of the MALT1 Tandem Ig-Like Domains
por: Qiu, Liyan, et al.
Publicado: (2011)

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways
por: Lian, Xiaolan, et al.
Publicado: (2018)

Correction to: Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways
por: Lian, Xiaolan, et al.
Publicado: (2018)

MERTK Interactions with SH2-Domain Proteins in the Retinal Pigment Epithelium
por: Shelby, Shameka J., et al.
Publicado: (2013)

Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME
por: Bacik, John-Paul, et al.
Publicado: (2010)

Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
por: Bezerra, Gustavo Arruda, et al.
Publicado: (2015)

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
por: Wei, Shuo, et al.
Publicado: (2015)

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations
por: de Araujo, Elvin D., et al.
Publicado: (2019)

Structure and Function of the PLAA/Ufd3-p97/Cdc48 Complex
por: Qiu, Liyan, et al.
Publicado: (2010)

Design and Characterization of Bivalent BET Inhibitors
por: Tanaka, Minoru, et al.
Publicado: (2016)

Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling
por: Achar, Yathish Jagadheesh, et al.
Publicado: (2015)

Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia
por: Zhou, Guang-Biao, et al.
Publicado: (2005)

Functional role of the flexible N-terminal extension of FKBP38 in catalysis
por: Kang, CongBao, et al.
Publicado: (2013)

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini
por: Ouyang, Hui, et al.
Publicado: (2012)

Structural insights into the inhibited states of the Mer receptor tyrosine kinase
por: Huang, Xudong, et al.
Publicado: (2009)

Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia
por: Ma, Ya-Fang, et al.
Publicado: (2022)

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
por: O’Meara, Timothy R., et al.
Publicado: (2022)

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells
por: Chew, Katherine, et al.
Publicado: (2022)

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives
por: McCulloch, Derek, et al.
Publicado: (2017)

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases
por: Davis, Tara L., et al.
Publicado: (2010)

Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress
por: Masciarelli, S, et al.
Publicado: (2018)

All-trans-retinoic-acid and arsenic trioxide induced remission in promyelocytic blast crisis
por: Colvin, Teresa A., et al.
Publicado: (2018)

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives [Corrigendum]
Publicado: (2017)

A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer
por: Tanton, Helen, et al.
Publicado: (2022)

Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line
por: Li, Nainong, et al.
Publicado: (2015)

Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms
por: Huang, Songyin, et al.
Publicado: (2019)

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
por: Prew, Michelle S., et al.
Publicado: (2022)

High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma
por: Garcha, Harsimran Kaur, et al.
Publicado: (2022)

Effects of arsenic trioxide, all-trans-retinoic acid and dexamethasone on NB4 cell line
por: Mandegary, A., et al.
Publicado: (2010)

Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells
por: Huynh, Thomas T., et al.
Publicado: (2019)

Arsenic and all-trans retinoic acid for acute promyelocytic leukemia: yes, it really is as good as it seems
por: Levis, Mark
Publicado: (2021)

Real world data with concurrent retinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia
por: Kulkarni, Uday P., et al.
Publicado: (2022)

Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line
por: Li, Xiaofan, et al.
Publicado: (2016)

Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma
por: McBride, Matthew J., et al.
Publicado: (2020)

The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma
por: McBride, Matthew J., et al.
Publicado: (2020)

Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival
por: Fukuda, Yusuke, et al.
Publicado: (2020)

Retinoic Acid and Arsenic Synergize to Eradicate Leukemic Cells in a Mouse Model of Acute Promyelocytic Leukemia
por: Lallemand-Breitenbach, Valérie, et al.
Publicado: (1999)

Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms
por: Tan, Ming, et al.
Publicado: (2019)

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
por: Nichols, Caitlin A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3qs8eicd1snvrmuvu1hgv4id0v