PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection against repeated exposure to S. pneumoniae, yet vaccines offer only partial protection. Patients with Activated PI3Kδ Syndrome (APDS) are highly su...

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Detalles Bibliográficos
Autores principales: Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085315/
https://www.ncbi.nlm.nih.gov/pubmed/30093657
http://dx.doi.org/10.1038/s41467-018-05674-8

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