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Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial can...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085317/ https://www.ncbi.nlm.nih.gov/pubmed/30093612 http://dx.doi.org/10.1038/s41467-018-05427-7 |
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| author | O’Mara, Tracy A. Glubb, Dylan M. Amant, Frederic Annibali, Daniela Ashton, Katie Attia, John Auer, Paul L. Beckmann, Matthias W. Black, Amanda Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brinton, Louise Buchanan, Daniel D. Burwinkel, Barbara Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Chen, Maxine M. Cheng, Timothy H. T. Clarke, Christine L. Clendenning, Mark Cook, Linda S. Couch, Fergus J. Cox, Angela Crous-Bous, Marta Czene, Kamila Day, Felix Dennis, Joe Depreeuw, Jeroen Doherty, Jennifer Anne Dörk, Thilo Dowdy, Sean C. Dürst, Matthias Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Friedenreich, Christine M. Fritschi, Lin Fung, Jenny García-Closas, Montserrat Gaudet, Mia M. Giles, Graham G. Goode, Ellen L. Gorman, Maggie Haiman, Christopher A. Hall, Per Hankison, Susan E. Healey, Catherine S. Hein, Alexander Hillemanns, Peter Hodgson, Shirley Hoivik, Erling A. Holliday, Elizabeth G. Hopper, John L. Hunter, David J. Jones, Angela Krakstad, Camilla Kristensen, Vessela N. Lambrechts, Diether Marchand, Loic Le Liang, Xiaolin Lindblom, Annika Lissowska, Jolanta Long, Jirong Lu, Lingeng Magliocco, Anthony M. Martin, Lynn McEvoy, Mark Meindl, Alfons Michailidou, Kyriaki Milne, Roger L. Mints, Miriam Montgomery, Grant W. Nassir, Rami Olsson, Håkan Orlow, Irene Otton, Geoffrey Palles, Claire Perry, John R. B. Peto, Julian Pooler, Loreall Prescott, Jennifer Proietto, Tony Rebbeck, Timothy R. Risch, Harvey A. Rogers, Peter A. W. Rübner, Matthias Runnebaum, Ingo Sacerdote, Carlotta Sarto, Gloria E. Schumacher, Fredrick Scott, Rodney J. Setiawan, V. Wendy Shah, Mitul Sheng, Xin Shu, Xiao-Ou Southey, Melissa C. Swerdlow, Anthony J. Tham, Emma Trovik, Jone Turman, Constance Tyrer, Jonathan P. Vachon, Celine VanDen Berg, David Vanderstichele, Adriaan Wang, Zhaoming Webb, Penelope M. Wentzensen, Nicolas Werner, Henrica M. J. Winham, Stacey J. Wolk, Alicja Xia, Lucy Xiang, Yong-Bing Yang, Hannah P. Yu, Herbert Zheng, Wei Pharoah, Paul D. P. Dunning, Alison M. Kraft, Peter De Vivo, Immaculata Tomlinson, Ian Easton, Douglas F. Spurdle, Amanda B. Thompson, Deborah J. |
| author_facet | O’Mara, Tracy A. Glubb, Dylan M. Amant, Frederic Annibali, Daniela Ashton, Katie Attia, John Auer, Paul L. Beckmann, Matthias W. Black, Amanda Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brinton, Louise Buchanan, Daniel D. Burwinkel, Barbara Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Chen, Maxine M. Cheng, Timothy H. T. Clarke, Christine L. Clendenning, Mark Cook, Linda S. Couch, Fergus J. Cox, Angela Crous-Bous, Marta Czene, Kamila Day, Felix Dennis, Joe Depreeuw, Jeroen Doherty, Jennifer Anne Dörk, Thilo Dowdy, Sean C. Dürst, Matthias Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Friedenreich, Christine M. Fritschi, Lin Fung, Jenny García-Closas, Montserrat Gaudet, Mia M. Giles, Graham G. Goode, Ellen L. Gorman, Maggie Haiman, Christopher A. Hall, Per Hankison, Susan E. Healey, Catherine S. Hein, Alexander Hillemanns, Peter Hodgson, Shirley Hoivik, Erling A. Holliday, Elizabeth G. Hopper, John L. Hunter, David J. Jones, Angela Krakstad, Camilla Kristensen, Vessela N. Lambrechts, Diether Marchand, Loic Le Liang, Xiaolin Lindblom, Annika Lissowska, Jolanta Long, Jirong Lu, Lingeng Magliocco, Anthony M. Martin, Lynn McEvoy, Mark Meindl, Alfons Michailidou, Kyriaki Milne, Roger L. Mints, Miriam Montgomery, Grant W. Nassir, Rami Olsson, Håkan Orlow, Irene Otton, Geoffrey Palles, Claire Perry, John R. B. Peto, Julian Pooler, Loreall Prescott, Jennifer Proietto, Tony Rebbeck, Timothy R. Risch, Harvey A. Rogers, Peter A. W. Rübner, Matthias Runnebaum, Ingo Sacerdote, Carlotta Sarto, Gloria E. Schumacher, Fredrick Scott, Rodney J. Setiawan, V. Wendy Shah, Mitul Sheng, Xin Shu, Xiao-Ou Southey, Melissa C. Swerdlow, Anthony J. Tham, Emma Trovik, Jone Turman, Constance Tyrer, Jonathan P. Vachon, Celine VanDen Berg, David Vanderstichele, Adriaan Wang, Zhaoming Webb, Penelope M. Wentzensen, Nicolas Werner, Henrica M. J. Winham, Stacey J. Wolk, Alicja Xia, Lucy Xiang, Yong-Bing Yang, Hannah P. Yu, Herbert Zheng, Wei Pharoah, Paul D. P. Dunning, Alison M. Kraft, Peter De Vivo, Immaculata Tomlinson, Ian Easton, Douglas F. Spurdle, Amanda B. Thompson, Deborah J. |
| author_sort | O’Mara, Tracy A. |
| collection | PubMed |
| description | Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. |
| format | Online Article Text |
| id | pubmed-6085317 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60853172018-08-13 Identification of nine new susceptibility loci for endometrial cancer O’Mara, Tracy A. Glubb, Dylan M. Amant, Frederic Annibali, Daniela Ashton, Katie Attia, John Auer, Paul L. Beckmann, Matthias W. Black, Amanda Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brinton, Louise Buchanan, Daniel D. Burwinkel, Barbara Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Chen, Maxine M. Cheng, Timothy H. T. Clarke, Christine L. Clendenning, Mark Cook, Linda S. Couch, Fergus J. Cox, Angela Crous-Bous, Marta Czene, Kamila Day, Felix Dennis, Joe Depreeuw, Jeroen Doherty, Jennifer Anne Dörk, Thilo Dowdy, Sean C. Dürst, Matthias Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Friedenreich, Christine M. Fritschi, Lin Fung, Jenny García-Closas, Montserrat Gaudet, Mia M. Giles, Graham G. Goode, Ellen L. Gorman, Maggie Haiman, Christopher A. Hall, Per Hankison, Susan E. Healey, Catherine S. Hein, Alexander Hillemanns, Peter Hodgson, Shirley Hoivik, Erling A. Holliday, Elizabeth G. Hopper, John L. Hunter, David J. Jones, Angela Krakstad, Camilla Kristensen, Vessela N. Lambrechts, Diether Marchand, Loic Le Liang, Xiaolin Lindblom, Annika Lissowska, Jolanta Long, Jirong Lu, Lingeng Magliocco, Anthony M. Martin, Lynn McEvoy, Mark Meindl, Alfons Michailidou, Kyriaki Milne, Roger L. Mints, Miriam Montgomery, Grant W. Nassir, Rami Olsson, Håkan Orlow, Irene Otton, Geoffrey Palles, Claire Perry, John R. B. Peto, Julian Pooler, Loreall Prescott, Jennifer Proietto, Tony Rebbeck, Timothy R. Risch, Harvey A. Rogers, Peter A. W. Rübner, Matthias Runnebaum, Ingo Sacerdote, Carlotta Sarto, Gloria E. Schumacher, Fredrick Scott, Rodney J. Setiawan, V. Wendy Shah, Mitul Sheng, Xin Shu, Xiao-Ou Southey, Melissa C. Swerdlow, Anthony J. Tham, Emma Trovik, Jone Turman, Constance Tyrer, Jonathan P. Vachon, Celine VanDen Berg, David Vanderstichele, Adriaan Wang, Zhaoming Webb, Penelope M. Wentzensen, Nicolas Werner, Henrica M. J. Winham, Stacey J. Wolk, Alicja Xia, Lucy Xiang, Yong-Bing Yang, Hannah P. Yu, Herbert Zheng, Wei Pharoah, Paul D. P. Dunning, Alison M. Kraft, Peter De Vivo, Immaculata Tomlinson, Ian Easton, Douglas F. Spurdle, Amanda B. Thompson, Deborah J. Nat Commun Article Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study. Nature Publishing Group UK 2018-08-09 /pmc/articles/PMC6085317/ /pubmed/30093612 http://dx.doi.org/10.1038/s41467-018-05427-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article O’Mara, Tracy A. Glubb, Dylan M. Amant, Frederic Annibali, Daniela Ashton, Katie Attia, John Auer, Paul L. Beckmann, Matthias W. Black, Amanda Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brinton, Louise Buchanan, Daniel D. Burwinkel, Barbara Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Chen, Maxine M. Cheng, Timothy H. T. Clarke, Christine L. Clendenning, Mark Cook, Linda S. Couch, Fergus J. Cox, Angela Crous-Bous, Marta Czene, Kamila Day, Felix Dennis, Joe Depreeuw, Jeroen Doherty, Jennifer Anne Dörk, Thilo Dowdy, Sean C. Dürst, Matthias Ekici, Arif B. Fasching, Peter A. Fridley, Brooke L. Friedenreich, Christine M. Fritschi, Lin Fung, Jenny García-Closas, Montserrat Gaudet, Mia M. Giles, Graham G. Goode, Ellen L. Gorman, Maggie Haiman, Christopher A. Hall, Per Hankison, Susan E. Healey, Catherine S. Hein, Alexander Hillemanns, Peter Hodgson, Shirley Hoivik, Erling A. Holliday, Elizabeth G. Hopper, John L. Hunter, David J. Jones, Angela Krakstad, Camilla Kristensen, Vessela N. Lambrechts, Diether Marchand, Loic Le Liang, Xiaolin Lindblom, Annika Lissowska, Jolanta Long, Jirong Lu, Lingeng Magliocco, Anthony M. Martin, Lynn McEvoy, Mark Meindl, Alfons Michailidou, Kyriaki Milne, Roger L. Mints, Miriam Montgomery, Grant W. Nassir, Rami Olsson, Håkan Orlow, Irene Otton, Geoffrey Palles, Claire Perry, John R. B. Peto, Julian Pooler, Loreall Prescott, Jennifer Proietto, Tony Rebbeck, Timothy R. Risch, Harvey A. Rogers, Peter A. W. Rübner, Matthias Runnebaum, Ingo Sacerdote, Carlotta Sarto, Gloria E. Schumacher, Fredrick Scott, Rodney J. Setiawan, V. Wendy Shah, Mitul Sheng, Xin Shu, Xiao-Ou Southey, Melissa C. Swerdlow, Anthony J. Tham, Emma Trovik, Jone Turman, Constance Tyrer, Jonathan P. Vachon, Celine VanDen Berg, David Vanderstichele, Adriaan Wang, Zhaoming Webb, Penelope M. Wentzensen, Nicolas Werner, Henrica M. J. Winham, Stacey J. Wolk, Alicja Xia, Lucy Xiang, Yong-Bing Yang, Hannah P. Yu, Herbert Zheng, Wei Pharoah, Paul D. P. Dunning, Alison M. Kraft, Peter De Vivo, Immaculata Tomlinson, Ian Easton, Douglas F. Spurdle, Amanda B. Thompson, Deborah J. Identification of nine new susceptibility loci for endometrial cancer |
| title | Identification of nine new susceptibility loci for endometrial cancer |
| title_full | Identification of nine new susceptibility loci for endometrial cancer |
| title_fullStr | Identification of nine new susceptibility loci for endometrial cancer |
| title_full_unstemmed | Identification of nine new susceptibility loci for endometrial cancer |
| title_short | Identification of nine new susceptibility loci for endometrial cancer |
| title_sort | identification of nine new susceptibility loci for endometrial cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085317/ https://www.ncbi.nlm.nih.gov/pubmed/30093612 http://dx.doi.org/10.1038/s41467-018-05427-7 |
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