The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates...

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Autores principales: Cellai, Lucrezia, Carvalho, Kevin, Faivre, Emilie, Deleau, Aude, Vieau, Didier, Buée, Luc, Blum, David, Mériaux, Céline, Gomez-Murcia, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085480/
https://www.ncbi.nlm.nih.gov/pubmed/30123104
http://dx.doi.org/10.3389/fnins.2018.00520
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author Cellai, Lucrezia
Carvalho, Kevin
Faivre, Emilie
Deleau, Aude
Vieau, Didier
Buée, Luc
Blum, David
Mériaux, Céline
Gomez-Murcia, Victoria
author_facet Cellai, Lucrezia
Carvalho, Kevin
Faivre, Emilie
Deleau, Aude
Vieau, Didier
Buée, Luc
Blum, David
Mériaux, Céline
Gomez-Murcia, Victoria
author_sort Cellai, Lucrezia
collection PubMed
description Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.
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spelling pubmed-60854802018-08-17 The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease Cellai, Lucrezia Carvalho, Kevin Faivre, Emilie Deleau, Aude Vieau, Didier Buée, Luc Blum, David Mériaux, Céline Gomez-Murcia, Victoria Front Neurosci Neuroscience Alzheimer’s disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics. Frontiers Media S.A. 2018-08-03 /pmc/articles/PMC6085480/ /pubmed/30123104 http://dx.doi.org/10.3389/fnins.2018.00520 Text en Copyright © 2018 Cellai, Carvalho, Faivre, Deleau, Vieau, Buée, Blum, Mériaux and Gomez-Murcia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cellai, Lucrezia
Carvalho, Kevin
Faivre, Emilie
Deleau, Aude
Vieau, Didier
Buée, Luc
Blum, David
Mériaux, Céline
Gomez-Murcia, Victoria
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title_full The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title_fullStr The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title_full_unstemmed The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title_short The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
title_sort adenosinergic signaling: a complex but promising therapeutic target for alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085480/
https://www.ncbi.nlm.nih.gov/pubmed/30123104
http://dx.doi.org/10.3389/fnins.2018.00520
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