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A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study.
Background: Cesarean delivery is performed under spinal anesthesia, and vasodilation is the main cause for a drop in blood pressure. The compression of the aorta and inferior vena cava by the gravid uterus is of additional clinical importance. Hypotension may occur during cesarean delivery even if p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085602/ https://www.ncbi.nlm.nih.gov/pubmed/30135733 http://dx.doi.org/10.12688/f1000research.15142.1 |
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author | Erango, Markos Frigessi, Arnoldo Rosseland, Leiv Arne |
author_facet | Erango, Markos Frigessi, Arnoldo Rosseland, Leiv Arne |
author_sort | Erango, Markos |
collection | PubMed |
description | Background: Cesarean delivery is performed under spinal anesthesia, and vasodilation is the main cause for a drop in blood pressure. The compression of the aorta and inferior vena cava by the gravid uterus is of additional clinical importance. Hypotension may occur during cesarean delivery even if prophylactic infusion of phenylephrine is practiced. We have tested if a 3 minute supine observation, can identify a subset of women with decreasing systolic arterial pressure (SAP) under spinal anesthesia. Methods: We performed a prospective observational study at Oslo University Hospital on healthy pregnant women for planned cesarean delivery. Continuous measurements of calibrated invasive SAP and estimated cardiac output were recorded for 76 women in a 3 minutes measurement with the woman in the left lateral position, followed by supine position for 3 minutes. Using functional data clustering, principal component analysis and curve smoothing, to filter way noise and reduce the dimensionality of the signal, we clustered the women into separate SAP groups. Results: We identified two significantly different groups of women during supine position; one characterized by initial drop in SAP, the other showed initial increase. After spinal anesthesia, the mean SAP curve of the women in the first group showed a drop in blood pressure, which was more rapid than for the other women. A minor difference in cardiac output was observed between the two groups of women with the mean cardiac output curve for the first group being higher. Conclusions: This work indicates that supine position affect clinically relevant cardiovascular measurements in pregnant women. A simple test may identify patients with increased risk of spinal anesthesia induced hypotension. |
format | Online Article Text |
id | pubmed-6085602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-60856022018-08-21 A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. Erango, Markos Frigessi, Arnoldo Rosseland, Leiv Arne F1000Res Research Article Background: Cesarean delivery is performed under spinal anesthesia, and vasodilation is the main cause for a drop in blood pressure. The compression of the aorta and inferior vena cava by the gravid uterus is of additional clinical importance. Hypotension may occur during cesarean delivery even if prophylactic infusion of phenylephrine is practiced. We have tested if a 3 minute supine observation, can identify a subset of women with decreasing systolic arterial pressure (SAP) under spinal anesthesia. Methods: We performed a prospective observational study at Oslo University Hospital on healthy pregnant women for planned cesarean delivery. Continuous measurements of calibrated invasive SAP and estimated cardiac output were recorded for 76 women in a 3 minutes measurement with the woman in the left lateral position, followed by supine position for 3 minutes. Using functional data clustering, principal component analysis and curve smoothing, to filter way noise and reduce the dimensionality of the signal, we clustered the women into separate SAP groups. Results: We identified two significantly different groups of women during supine position; one characterized by initial drop in SAP, the other showed initial increase. After spinal anesthesia, the mean SAP curve of the women in the first group showed a drop in blood pressure, which was more rapid than for the other women. A minor difference in cardiac output was observed between the two groups of women with the mean cardiac output curve for the first group being higher. Conclusions: This work indicates that supine position affect clinically relevant cardiovascular measurements in pregnant women. A simple test may identify patients with increased risk of spinal anesthesia induced hypotension. F1000 Research Limited 2018-07-09 /pmc/articles/PMC6085602/ /pubmed/30135733 http://dx.doi.org/10.12688/f1000research.15142.1 Text en Copyright: © 2018 Erango M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Erango, Markos Frigessi, Arnoldo Rosseland, Leiv Arne A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title | A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title_full | A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title_fullStr | A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title_full_unstemmed | A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title_short | A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study. |
title_sort | three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. an observational study. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085602/ https://www.ncbi.nlm.nih.gov/pubmed/30135733 http://dx.doi.org/10.12688/f1000research.15142.1 |
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