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TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis

BACKGROUND: Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-suppressing STF cDNA 3 (TSSC3) functions as an imprinted tumor suppressor gene...

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Detalles Bibliográficos
Autores principales:	Zhao, Guo-sheng, Gao, Zi-ran, Zhang, Qiao, Tang, Xue-feng, Lv, Yang-fan, Zhang, Zhao-si, Zhang, Yuan, Tan, Qiu-lin, Peng, Dong-bin, Jiang, Dian-ming, Guo, Qiao-Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085607/ https://www.ncbi.nlm.nih.gov/pubmed/30092789 http://dx.doi.org/10.1186/s13046-018-0856-6

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