Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

BACKGROUND: Upregulation of human epidermal growth factor receptor 3 (HER3) is a major mechanism of acquired resistance to therapies targeting its heterodimerization partners epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), but also exposes HER3 as a targe...

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Detalles Bibliográficos
Autores principales: Osada, Takuya, Hartman, Zachary C., Wei, Junping, Lei, Gangjun, Hobeika, Amy C., Gwin, William R., Diniz, Marcio A., Spector, Neil, Clay, Timothy M., Chen, Wei, Morse, Michael A., Lyerly, H. Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085609/
https://www.ncbi.nlm.nih.gov/pubmed/30092835
http://dx.doi.org/10.1186/s13058-018-1023-x

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