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The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome

BACKGROUND: Peutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway. METHODS: PJS probands with STK11 mutation were included in the function analysis. P53 activity elevated by STK11 mutants was invest...

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Detalles Bibliográficos
Autores principales:	Jiang, Yu-Liang, Zhao, Zi-Ye, Li, Bai-Rong, Yang, Fu, Li, Jing, Jin, Xiao-Wei, Wang, Hao, Yu, En-Da, Sun, Shu-Han, Ning, Shou-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085611/ https://www.ncbi.nlm.nih.gov/pubmed/30092773 http://dx.doi.org/10.1186/s12881-018-0626-5

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