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Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database
BACKGROUND: The sinuses, nasal cavity, and middle ear represent a rarer location of head and neck malignancy than more common sites such as the larynx and oral cavity. Population-based studies are a useful tool to study the demographic and treatment factors affecting survival in these malignancies....
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085622/ https://www.ncbi.nlm.nih.gov/pubmed/30116158 http://dx.doi.org/10.1186/s12901-018-0061-4 |
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author | Gore, Mitchell R. |
author_facet | Gore, Mitchell R. |
author_sort | Gore, Mitchell R. |
collection | PubMed |
description | BACKGROUND: The sinuses, nasal cavity, and middle ear represent a rarer location of head and neck malignancy than more common sites such as the larynx and oral cavity. Population-based studies are a useful tool to study the demographic and treatment factors affecting survival in these malignancies. METHODS: Population-based database search of the Survival, Epidemiology, and End Results (SEER) database from 1973 to 2015 for malignancies involving the nasal cavity, paranasal sinuses, and middle ear. Data were analyzed for demographics, treatment type, stage, primary site and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival. RESULTS: A total of 13,992 cases of sinonasal or middle ear malignancy were identified and analyzed. The majority of patients were between ages 50 and 80 at the time of diagnosis. Overall 5-, 10-, and 20-year survival was 45.7%, 32.2%, and 16.4%, respectively. Lymph node metastasis was reported in 4.4% of patients, while distant metastasis was present in 1.5% of cases. On univariate analysis surgical vs. nonsurgical treatment, sex, race, age at diagnosis, T stage, N stage, M stage, AJCC overall stage, primary site, tumor grade, and histopathologic subtype significantly affected survival. On multivariate analysis age, race, sex, primary site, overall AJCC stage, surgical vs. nonsurgical treatment, and T, N, and M stage remained significant predictors of overall survival. CONCLUSIONS: Malignancies of the nasal cavity, paranasal sinuses, and middle ear account for a minority of overall head and neck cancers. The overall 5-, 10-, and 20-year survival for these malignancies is relatively low. Higher T, N, M, and overall stage and higher tumor grade is associated with lower survival. Patients treated with surgery as part of the treatment regimen had higher overall survival. Demographics and primary site also significantly affect survival. Certain histopathologic subtypes were associated with poorer survival. |
format | Online Article Text |
id | pubmed-6085622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60856222018-08-16 Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database Gore, Mitchell R. BMC Ear Nose Throat Disord Research Article BACKGROUND: The sinuses, nasal cavity, and middle ear represent a rarer location of head and neck malignancy than more common sites such as the larynx and oral cavity. Population-based studies are a useful tool to study the demographic and treatment factors affecting survival in these malignancies. METHODS: Population-based database search of the Survival, Epidemiology, and End Results (SEER) database from 1973 to 2015 for malignancies involving the nasal cavity, paranasal sinuses, and middle ear. Data were analyzed for demographics, treatment type, stage, primary site and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival. RESULTS: A total of 13,992 cases of sinonasal or middle ear malignancy were identified and analyzed. The majority of patients were between ages 50 and 80 at the time of diagnosis. Overall 5-, 10-, and 20-year survival was 45.7%, 32.2%, and 16.4%, respectively. Lymph node metastasis was reported in 4.4% of patients, while distant metastasis was present in 1.5% of cases. On univariate analysis surgical vs. nonsurgical treatment, sex, race, age at diagnosis, T stage, N stage, M stage, AJCC overall stage, primary site, tumor grade, and histopathologic subtype significantly affected survival. On multivariate analysis age, race, sex, primary site, overall AJCC stage, surgical vs. nonsurgical treatment, and T, N, and M stage remained significant predictors of overall survival. CONCLUSIONS: Malignancies of the nasal cavity, paranasal sinuses, and middle ear account for a minority of overall head and neck cancers. The overall 5-, 10-, and 20-year survival for these malignancies is relatively low. Higher T, N, M, and overall stage and higher tumor grade is associated with lower survival. Patients treated with surgery as part of the treatment regimen had higher overall survival. Demographics and primary site also significantly affect survival. Certain histopathologic subtypes were associated with poorer survival. BioMed Central 2018-08-09 /pmc/articles/PMC6085622/ /pubmed/30116158 http://dx.doi.org/10.1186/s12901-018-0061-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Gore, Mitchell R. Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title | Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title_full | Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title_fullStr | Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title_full_unstemmed | Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title_short | Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database |
title_sort | survival in sinonasal and middle ear malignancies: a population-based study using the seer 1973–2015 database |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085622/ https://www.ncbi.nlm.nih.gov/pubmed/30116158 http://dx.doi.org/10.1186/s12901-018-0061-4 |
work_keys_str_mv | AT goremitchellr survivalinsinonasalandmiddleearmalignanciesapopulationbasedstudyusingtheseer19732015database |