Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

BACKGROUND: Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and glial cells. Toll-like receptor 2...

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Detalles Bibliográficos
Autores principales: Kim, Changyoun, Spencer, Brian, Rockenstein, Edward, Yamakado, Hodaka, Mante, Michael, Adame, Anthony, Fields, Jerel Adam, Masliah, Deborah, Iba, Michiyo, Lee, He-Jin, Rissman, Robert A., Lee, Seung-Jae, Masliah, Eliezer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085656/
https://www.ncbi.nlm.nih.gov/pubmed/30092810
http://dx.doi.org/10.1186/s13024-018-0276-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085656/
https://www.ncbi.nlm.nih.gov/pubmed/30092810
http://dx.doi.org/10.1186/s13024-018-0276-2

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