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DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
Fragment-based lead discovery has proven to be a powerful method in the drug discovery process. The combinatorial output that is accessible by combining fragments is very attractive; however, identifying fragment pairs that bind synergistically and linking them productively can be challenging. Sever...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085657/ https://www.ncbi.nlm.nih.gov/pubmed/30154995 http://dx.doi.org/10.1039/c4sc01654h |