Counteracting roles of MHCI and CD8(+) T cells in the peripheral and central nervous system of ALS SOD1(G93A) mice

BACKGROUND: The major histocompatibility complex I (MHCI) is a key molecule for the interaction of mononucleated cells with CD8(+)T lymphocytes. We previously showed that MHCI is upregulated in the spinal cord microglia and motor axons of transgenic SOD1(G93A) mice. METHODS: To assess the role of MH...

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Detalles Bibliográficos
Autores principales: Nardo, Giovanni, Trolese, Maria Chiara, Verderio, Mattia, Mariani, Alessandro, de Paola, Massimiliano, Riva, Nilo, Dina, Giorgia, Panini, Nicolò, Erba, Eugenio, Quattrini, Angelo, Bendotti, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085701/
https://www.ncbi.nlm.nih.gov/pubmed/30092791
http://dx.doi.org/10.1186/s13024-018-0271-7

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