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Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells

Mouse models have shown that a disintegrin A metalloprotease 12 (ADAM12) is implicated during adipogenesis; the molecular pathways are not well understood. Stealth RNA interference was used to knock down ADAM12 in 3T3-L1 cells. Using gene profiling and metabolic enzymatic markers, we have identified...

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Detalles Bibliográficos
Autores principales:	Coles, Chantal A., Maksimovic, Jovana, Wadeson, Jenny, Fahri, Fahri T., Webster, Tracie, Leyton, Carolina, McDonagh, Matthew B., White, Jason D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085825/ https://www.ncbi.nlm.nih.gov/pubmed/29846135 http://dx.doi.org/10.1091/mbc.E17-07-0471

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