Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...

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Detalles Bibliográficos
Autores principales: Gabriel, Heloisa B, Azevedo, Mauro F, Kimura, Emília A, Katzin, Alejandro M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086031/
https://www.ncbi.nlm.nih.gov/pubmed/30110072
http://dx.doi.org/10.1590/0074-02760180174
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author Gabriel, Heloisa B
Azevedo, Mauro F
Kimura, Emília A
Katzin, Alejandro M
author_facet Gabriel, Heloisa B
Azevedo, Mauro F
Kimura, Emília A
Katzin, Alejandro M
author_sort Gabriel, Heloisa B
collection PubMed
description Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.
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spelling pubmed-60860312018-08-17 Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate Gabriel, Heloisa B Azevedo, Mauro F Kimura, Emília A Katzin, Alejandro M Mem Inst Oswaldo Cruz Short Communication Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs. Instituto Oswaldo Cruz, Ministério da Saúde 2018-08-13 /pmc/articles/PMC6086031/ /pubmed/30110072 http://dx.doi.org/10.1590/0074-02760180174 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Gabriel, Heloisa B
Azevedo, Mauro F
Kimura, Emília A
Katzin, Alejandro M
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_full Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_fullStr Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_full_unstemmed Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_short Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_sort plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086031/
https://www.ncbi.nlm.nih.gov/pubmed/30110072
http://dx.doi.org/10.1590/0074-02760180174
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