Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...

Descripción completa

Detalles Bibliográficos
Autores principales: Gabriel, Heloisa B, Azevedo, Mauro F, Kimura, Emília A, Katzin, Alejandro M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086031/
https://www.ncbi.nlm.nih.gov/pubmed/30110072
http://dx.doi.org/10.1590/0074-02760180174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086031/
https://www.ncbi.nlm.nih.gov/pubmed/30110072
http://dx.doi.org/10.1590/0074-02760180174

Ejemplares similares