High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

In vivo direct conversion of differentiated cells holds promise for regenerative medicine; however, improving the conversion efficiency and producing functional target cells remain challenging. Ectopic Atoh1 expression in non-sensory supporting cells (SCs) in mouse cochleae induces their partial con...

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Detalles Bibliográficos
Autores principales: Yamashita, Tetsuji, Zheng, Fei, Finkelstein, David, Kellard, Zoe, Carter, Robert, Rosencrance, Celeste D., Sugino, Ken, Easton, John, Gawad, Charles, Zuo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086484/
https://www.ncbi.nlm.nih.gov/pubmed/30063705
http://dx.doi.org/10.1371/journal.pgen.1007552

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